Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure
Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure
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DOI：
10.1097/00005344-200110001-00017
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发表时间：
2001-10-01
影响因子：
3
通讯作者：
Kinoshita, M
中科院分区：
文献类型：
--
作者：
Tsutsui, T;Tsutamoto, T;Kinoshita, M
我们评估了短效袢利尿剂呋塞米和长效袢利尿剂阿佐塞米对充血性心力衰竭（CHF）患者神经体液因子和生活质量（QOL）的比较效果。对25名病情稳定的轻度慢性充血性心力衰竭患者进行了研究，这些患者口服呋塞米（n = 14）或阿佐塞米（n = 11）已超过3个月。我们将呋塞米换为阿佐塞米，或将阿佐塞米换为呋塞米，并随访3个月。进行了超声心动图检查，还测量了神经体液因子，并通过问卷调查评估了生活质量。在呋塞米和阿佐塞米治疗期间，血压、体重、肾功能和超声心动图结果相同。两种治疗方法中心房利钠肽和脑利钠肽的血浆水平没有差异。然而，呋塞米治疗时活性肾素和去甲肾上腺素的血浆浓度显著高于阿佐塞米治疗时。阿佐塞米治疗的生活质量评分显著低于呋塞米治疗。这些发现表明，在轻度充血性心力衰竭患者中，长效袢利尿剂对神经内分泌系统和生活质量的不良影响可能比短效袢利尿剂少。
We evaluated the comparative effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting loop diuretic, on neurohumoral factors and quality of life (QOL) in patients with congestive heart failure (CHF). Twenty-five stable patients with mild chronic CHF who had been administered furosemide (n = 14) or azosemide (n = 11) orally for more than 3 months were studied. We changed furosemide to azosemide or azosemide to furosemide and followed for 3 months. Echocardiography was performed, and we also measured neurohumoral factors and assessed QOL by questionnaire. Blood pressure, body weight, renal function and echocardiographic findings were the same during the furosemide and azosemide treatments. Plasma levels of atrial natriuretic peptide and brain natriuretic peptide were not different between the two treatments. However, plasma concentrations of active renin and norepinephrine were significantly higher with furosemide treatment than with azosemide treatment. QOL score was significantly lower with azosemide than with furosemide. These findings suggest that long-acting loop diuretics may have fewer adverse effects on the neuroendocrine system and QOL than short-acting loop diuretics in patients with mild CHF.