RSV hospitalisation and healthcare utilisation in moderately prematurely born infants.
RSV hospitalisation and healthcare utilisation in moderately prematurely born infants.
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DOI：
10.1007/s00431-012-1673-0
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发表时间：
2012-07
影响因子：
3.6
通讯作者：
Greenough A
中科院分区：
文献类型：
--
作者：
Shefali-Patel D;Paris MA;Watson F;Peacock JL;Campbell M;Greenough A
呼吸道合胞病毒（RSV）感染与早产儿慢性呼吸道疾病有关。我们的目的是确定中度早产（妊娠32-35周）的婴儿是否有RSV住院治疗，与没有住院治疗的婴儿相比，在头2年内有更高的医疗保健利用率和相关的护理成本。检查了2666名符合条件的婴儿记录，以确定三组：20名婴儿因RSV下呼吸道感染（RSV）入院，30名因另一种呼吸问题（其他呼吸问题）入院，108名因非呼吸问题/从未入院（非呼吸问题）。通过检查医院和全科医生的记录和使用国家参考成本计划和英国国家处方价格计算的护理成本来评估医疗保健利用情况。RSV组的平均护理费用（12,505英镑）高于非呼吸系统组（1,178英镑）（95% CI差异为5,015英镑至17,639英镑，p = 0.002）和其他呼吸系统组（3,356英镑）（95% CI差异为2,963英镑至15,606英镑，p < 0.001）。RSV组和非呼吸系统组的调整后平均护理费用差异为11,186英镑（95% CI为4,763英镑至17,609英镑），RSV组和其他呼吸系统组的调整后平均护理费用差异为9,076英镑（95% CI为2,515英镑至15,637英镑）。2066名符合条件的婴儿中有42名因呼吸道合胞病毒住院（2%）；因此，假设预防将使住院率降低50%，则需要治疗的人数为98人。总之，中度早产婴儿的呼吸道合胞病毒住院治疗与健康相关护理费用增加有关。然而，如果要使RSV预防具有成本效益，需要确定中度早产婴儿的高风险群体。
Respiratory syncytial virus (RSV) infection is associated with chronic respiratory morbidity in infants born very prematurely. Our aims were to determine if infants born moderately prematurely (32–35 weeks of gestation) who had had an RSV hospitalisation, compared to those who had not, had greater healthcare utilisation and related cost of care in the first 2 years. Two thousand and sixty-six eligible infants’ records were examined to identify three groups: 20 infants admitted for an RSV lower respiratory tract infection (RSV), 30 admitted for another respiratory problem (other respiratory) and 108 admitted for a non-respiratory problem/never admitted (non-respiratory). Healthcare utilisation was assessed by examining hospital and general practitioner records and cost of care calculated using the National Scheme of Reference costs and the British National Formulary prices. The mean cost of care in the RSV group (£12,505) was greater than the non-respiratory (£1,178) (95% CI for difference £5,015 to £17,639, p = 0.002) and the other respiratory (£3,356) groups (95% CI for difference £2,963 to £15,606, p < 0.001). The adjusted mean differences in the cost of care were £11,186 between the RSV and non-respiratory groups (95% CI £4,763 to £17,609) and £9,076 (95% CI £2,515 to £15,637) between the RSV and the other respiratory groups. Forty-two of 2,066 eligible infants had an RSV hospitalisation (2%); thus, assuming prophylaxis would reduce the hospitalisation rate by 50%, the number needed to treat was 98. In conclusion, RSV hospitalisation in moderately prematurely born infants is associated with increased health-related cost of care. Nevertheless, if RSV prophylaxis is to be cost-effective, a high risk group of moderately prematurely born infants needs to be identified.
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影响因子：
--
作者：
Thompson, SG;Barber, JA
通讯作者：
Barber, JA
DOI：
10.1016/j.jaci.2010.05.026
发表时间：
2010-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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通讯作者：
Palivizumab Long-Term Respiratory Outcomes Study Group
影响因子：
5.1
作者：
WANG, EEL;LAW, BJ;HAMMOND, G
通讯作者：
HAMMOND, G
影响因子：
8
作者：
Null, D;Bimle, C;Top, FH
通讯作者：
Top, FH
影响因子：
3.6
作者：
Broughton, Simon;Sylvester, Karl P.;Greenough, Anne
通讯作者：
Greenough, Anne