Optical and FDG mapping of frequency-specific activity in auditory cortex
Optical and FDG mapping of frequency-specific activity in auditory cortex
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DOI：
10.1097/00001756-199611040-00047
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发表时间：
1996-11-04
期刊：
影响因子：
1.7
通讯作者：
Scheich, H
中科院分区：
文献类型：
--
作者：
Hess, A;Scheich, H
通过内在信号（ORIS）和音调刺激的光学记录，我们分析了清醒蒙古沙鼠初级听觉皮层 Al 中频率和强度依赖性的时空活动。我们发现 ORIS 活动的二维和不对称传播（1）在所有频率下沿着等频率轮廓从腹侧到背侧，以及（2）在低频下从低频端穿过完整的音调梯度。高频表征仍然是主题。音调不对称与刺激强度无关。相比之下，在来自同一动物的氟-2-脱氧葡萄糖图像中，代谢活动在高频和低频上受到音调限制。 ORIS 活动的不对称音调传播表明皮质网络中的阈下定向相互作用机制可能有助于将复杂声音的低频分量与高频分量相关联
WITH optical recording of intrinsic signals (ORIS) and tone stimulation, we analysed frequency- and intensity-dependent spatio-temporal activity in primary auditory cortex Al of awake Mongolian gerbils. We found a two-dimensional and assymetric propagation of ORIS activity (1) from ventral to dorsal along isofrequency contours at all frequencies and (2) from the low-frequency end across the complete tonotopic gradient at low frequencies. High-frequency representations remained tonotopic. Tonotopic asymmetries were independent of stimulus intensity. By contrast, in fluoro-2-deoxyglucose images from the same animals metabolic activity was tonotopically confined at high and low frequencies. The assymetric tonotopic propagation of ORIS activity suggests subthreshold directional interaction mechanisms in the cortical network which may serve to relate low- to high-frequency components of complex sounds