Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States
Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States
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DOI：
10.1177/1352458508101933
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发表时间：
2009-05-01
期刊：
影响因子：
--
通讯作者：
Healy, B.
中科院分区：
文献类型：
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作者：
Chitnis, T.;Glanz, B.;Healy, B.
目的在一大群MS患者中，我们试图确定18岁以下首发症状的比例，并将他们的人口学和疾病特征与典型的成人起病MS人群进行比较。方法在马萨诸塞州波士顿布里格姆妇女医院的合作伙伴多发性硬化症中心就诊的患者，将临床病史和首发症状特征记录在电子数据库中，结果有MS病史的患者中，3.06%的患者首次发病年龄在18岁以下，而30.83%的患者首次发病年龄在25-35岁之间。除了青春期前患者中女性比例较低外，两组患者的性别比例相似。在年轻的队列中，非高加索人的比例更高。两组患者的首发症状部位相似。结论约3%的MS患者在18岁前出现首发症状。在儿童时期首次脱髓鞘发作后，需要进行标准化的随访，这可能会导致儿童多发性硬化症的早期诊断和治疗；15：627-631。Http://msj.sagepub.com
Background The prevalence of pediatric-onset multiple sclerosis (MS) in the United States is unknown.Objective In a large cohort of MS patients, we sought to identify the proportion with first symptom-onset below the age of 18 years, and to compare their demographic and disease characteristics to a typical adult-onset MS population.Methods Patients seen at the Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, Massachusetts, with clinical histories and characteristics of first symptoms recorded in an electronic database, were included in this study.Results We found that 3.06% of patients with a recorded MS history experienced a first attack under the age of 18 years of age compared to 30.83% of patients who experienced first symptoms between the ages of 25-35 years. Gender proportions were similar in both groups, with the exception of a lower female preponderance in pre-pubertal-onset patients. There was a higher proportion of non-Caucasians in the younger cohort. Localization of first symptoms was similar in the two groups.Conclusion About 3% of MS patients experience their first symptom prior to the age of 18 years. Standardized follow-up is required after a first demyelinating attack in childhood, which may lead to earlier diagnosis and treatment of pediatric-onset MS. Multiple Sclerosis 2009; 15: 627-631. http://msj.sagepub.com