Asymmetric Henry Reaction of 2-Acylpyridine N-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst
Asymmetric Henry Reaction of 2-Acylpyridine N-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst
复制标题
Ni-氨基苯酚磺酰胺配合物催化 2-酰基吡啶 N-氧化物的不对称亨利反应：一种意想不到的单核催化剂
DOI：
10.3390/molecules24081471
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发表时间：
2019-04
期刊：
影响因子：
4.6
通讯作者：
Zhou Hui
中科院分区：
文献类型：
--
作者：
Liu Mouxiong;Gui Dongdong;Deng Ping;Zhou Hui
The asymmetric Henry reaction of 2-acylpyridine N-oxide remains a challenge as N-oxides generally act as competitive catalyst inhibitors or displace activating ligands. A novel variable yield (up to 99%) asymmetric Henry reaction of 2-acypyridine N-oxides catalyzed by a Ni-aminophenol sulfonamide complex with good to excellent enantioselectivity (up to 99%) has been developed. Mechanistic studies suggest that the unique properties of the electron-pairs of N-oxides for complexation with Ni makes the unexpected mononuclear complex, rather than the previously reported dinuclear complex, the active species.
