Relation between chemotherapy dose, oestrogen receptor expression, and body-mass index
Relation between chemotherapy dose, oestrogen receptor expression, and body-mass index
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DOI：
10.1016/s0140-6736(05)67110-3
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发表时间：
2005-09-24
期刊：
影响因子：
168.9
通讯作者：
Goldhirsch, A
中科院分区：
文献类型：
--
作者：
Colleoni, M;Li, SG;Goldhirsch, A
临床医生在治疗肥胖患者时经常减少化疗剂量，因为担心过量。我们根据体重指数（BMI）和雌激素受体（ER）表达的原发性肿瘤在绝经前淋巴结阳性乳腺癌患者与经典CMF（环磷酰胺，甲氨蝶呤，5-氟尿嘧啶）治疗的剂量反应进行了评估。肥胖患者更可能接受较低的化疗剂量（
Clinicians often reduce chemotherapy doses when treating obese patients because of concerns about overdosing. We assessed dose-response according to body-mass index (BMI) and oestrogen receptor (ER) expression of the primary tumour in premenopausal patients with node-positive breast cancer treated with classical CMF (cyclophosphamide, methotrexate, and 5-fluorouracil). Obese patients were significantly more likely to receive a lower chemotherapy dose (