Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging
Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging
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DOI：
10.1016/j.canlet.2010.08.004
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发表时间：
2010-12-18
期刊：
影响因子：
9.7
通讯作者：
Chang, Kiyuk
中科院分区：
文献类型：
--
作者：
Cho, Young-Seok;Yoon, Tae-Jong;Chang, Kiyuk
磁荧光二氧化硅纳米颗粒与西妥昔单抗结合用于结肠癌的靶向和成像。MFSN-Ctx可以特异性靶向在其细胞膜上表达EGFR的结肠癌细胞，并且检测到特异性荧光MFSN-Ctx在人结肠癌异种移植小鼠模型中产生显著的MRI信号变化。与腹膜内注射相比，Ctx导致更快的摄取，这表明MFSN-Ctx在肿瘤中具有基于注射方法的不同动力学性质。通过使用外部磁场放大MFSN-Ctx在肿瘤中的局部浓度。这些结果证明MFSN-Ctx用于检测EGFR的潜在应用。使用体内成像方法表达结肠癌（C）2010 Elsevier爱尔兰有限公司版权所有
Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer In this study cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes and specific fluorescence was detected MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches (C) 2010 Elsevier Ireland Ltd All rights reserved