Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases.
Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases.
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DOI：
10.3389/fnmol.2021.720371
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zheng P
中科院分区：
文献类型：
--
作者：
Cui D;Jiang X;Chen M;Sheng H;Shao D;Yang L;Guo X;Wang Y;Lai B;Zheng P
Rac1是Rho家族的一个小gtp酶。先前的一项研究表明，Rac1的激活对海马长期增强（LTP）的诱导和维持具有相反的作用。然而，这种相反作用的分子机制仍有待研究。在目前的研究中，我们发现在LTP的诱导过程中，Rac1的激活导致PKCι/λ被磷脂酰肌醇-3激酶（PI3K）激活，而在LTP的维持过程中，Rac1的激活导致海马中LIM_kinase （LIMK）抑制PKMζ。该结果提示，在LTP的不同阶段，Rac1的激活可以调节不同的信号通路，从而对海马LTP的诱导和维持产生相反的作用。
Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opposing effect remains to be addressed. In the present work, we find that the activation of Rac1 during the induction of LTP leads to an activation of PKCι/λ by phosphatidylinositol-3-kinase (PI3K), whereas the activation of Rac1 during the maintenance of LTP leads to the inhibition of PKMζ by LIM_kinase (LIMK) in the hippocampus. This result suggests that during different stages of LTP, the activation of Rac1 can modulate different signaling pathways, which leads to an opposing effect on the induction and maintenance of LTP in the hippocampus.
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