Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules.

Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules.
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脐带血干细胞移植后出现与肺结节相关的 Epstein-Barr 病毒相关移植后淋巴细胞增殖性疾病。

DOI:
10.1097/00043426-200402000-00015
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发表时间:
2004
期刊:
Journal of pediatric hematology/oncology
影响因子:
--
通讯作者:
S. Okamoto
S. Okamoto
中科院分区:
--
文献类型:
--
作者:
N. Shimasaki;T. Mori;H. Shimada;M. Sugita;Masataka Higuchi;M. Mukai;T. Morio;S. Okamoto

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Sixteen months after a cord blood stem cell transplantation, a 6-year-old girl was diagnosed with Epstein-Barr virus-associated posttransplant lymphoproliferative disorder (EBV-PTLD). A CT scan revealed nodules in both lungs, but the patient had neither lymphadenopathy nor other lesions. The diagnosis was confirmed by histopathologic evaluation and the increased level of EBV DNA in the peripheral blood. The patient was successfully treated with rituximab, and a complete regression of the tumors was achieved. This case reveals the need to include EBV-PTLD in the differential diagnosis of pulmonary nodules, as well as demonstrating that rituximab may be effective treatment of EBV-PTLD after cord blood stem cell transplantation.
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