The value of circulating lymphocytic subpopulations in the diagnosis and repair of ischemic stroke patients with dizziness.
The value of circulating lymphocytic subpopulations in the diagnosis and repair of ischemic stroke patients with dizziness.
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循环淋巴细胞亚群在缺血性脑卒中头晕患者诊断和修复中的价值。
DOI：
10.3389/fnagi.2022.1042123
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
确定头晕是否是导致中风的主要原因仍然具有挑战性。本研究旨在探索临床生物标志物，用于识别缺血性中风患者和头晕患者并预测其长期康复。 2018年1月至2019年6月，本研究招募了21名以头晕为主要主诉的缺血性脑卒中患者、84名非脑卒中头晕患者和87名健康志愿者。然后采集外周血样本，检测循环淋巴细胞T细胞、CD4+T细胞、CD8+T细胞、T−/−细胞（DNTs）、CD4+调节性T细胞（Tregs）、CD8+Tregs、B细胞和调节性B细胞（Bregs）的百分比，以确定具有临床价值的生物标志物。根据我们的数据，非中风眩晕患者和缺血性中风眩晕患者之间的 DNT 比例存在显着差异（p = 0.0009）。缺血性脑卒中合并头晕患者的Bregs比例低于非脑卒中头晕患者（p = 0.035）。此外，患者外周血淋巴细胞中Bregs和DNTs的百分比与卒中发生呈显着负相关（Bregs，p = 0.039；DNTs，p = 0.046）。此外，淋巴细胞内的Bregs和DNT与参与者的年龄呈负相关，而与吸烟、高血压和糖尿病等临床风险的关系较弱。然后，Bregs和DNTs一起的受试者工作特征曲线下面积（AUC）为0.768，危险因素和Bregs或DNTs的范围分别为0.795和0.792，并且危险因素、Bregs和DNTs组合的AUC值进一步增加至0.815。此外，入院时淋巴细胞内的 Bregs 百分比也是出院时及接下来 3 个月内修复的潜在预测因子。 Bregs 和 DNT 可以一起作为临床生物标志物，用于识别缺血性中风患者和头晕患者。
To determine whether dizziness can contribute to stroke as a main cause still remains challenging. This study aims to explore clinical biomarkers in the identification of ischemic stroke patients from people with dizziness and the prediction of their long-term recovery. From January 2018 to June 2019, 21 ischemic stroke patients with a main complaint of dizziness, 84 non-stroke dizziness patients and 87 healthy volunteers were recruited in this study. Then, their peripheral blood samples were collected, and the percentages of circulating lymphocytes T cells, CD4+ T cells, CD8+ T cells, T−/− cells (DNTs), CD4+ regulatory T cells (Tregs), CD8+ Tregs, B cells and regulatory B cells (Bregs) were examined to identify biomarkers with clinical value. According to our data, a significant difference in the DNTs proportion was detected between non-stroke dizziness and ischemic stroke patients with dizziness (p = 0.0009). The Bregs proportion in ischemic stroke patients with dizziness was lower than that in non-stroke dizziness patients (p = 0.035). In addition, the percentage of Bregs and DNTs within lymphocytes in patients’ peripheral blood exhibited a significant negative correlation with stroke occurrence (Bregs, p = 0.039; DNTs, p = 0.046). Moreover, the Bregs and DNTs within lymphocytes were negatively related to participants’ age, while presented a weak relationship with clinical risks like smoking, hypertension, and diabetes. Then, area under the receiver operating characteristic curve (AUC) of Bregs and DNTs together was 0.768, the risk factors and Bregs or DNTs ranged from 0.795 and 0.792, respectively, and the AUC value of risk factors, Bregs and DNTs combination was further increased to 0.815. Furthermore, the Bregs percentage within lymphocytes at admission was also a potential predictor of repair at discharge and the following 3 months. Bregs and DNTs could be the clinical biomarkers together in the identification of ischemic stroke patients from people with dizziness.
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影响因子：
5.4
作者：
Ford, Megan S.;Chen, Wenhao;Zhang, Li
通讯作者：
Zhang, Li
影响因子：
8.3
作者：
Aigner, Annette;Grittner, Ulrike;Busch, Markus A.
通讯作者：
Busch, Markus A.
中国脑卒中及其亚型的危险因素：一项前瞻性研究
影响因子：
5.4
作者：
Qi W;Ma J;Guan T;Zhao D;Abu-Hanna A;Schut M;Chao B;Wang L;Liu Y
通讯作者：
Liu Y
影响因子：
9.9
作者：
Richoz, Benjamin;Hugli, Olivier;Michel, Patrik
通讯作者：
Michel, Patrik
影响因子：
5.7
作者：
Feigin VL;Krishnamurthi RV;Parmar P;Norrving B;Mensah GA;Bennett DA;Barker-Collo S;Moran AE;Sacco RL;Truelsen T;Davis S;Pandian JD;Naghavi M;Forouzanfar MH;Nguyen G;Johnson CO;Vos T;Meretoja A;Murray CJ;Roth GA;GBD 2013 Writing Group;GBD 2013 Stroke Panel Experts Group
通讯作者：
GBD 2013 Stroke Panel Experts Group