Hyperoxia during one lung ventilation: inflammatory and oxidative responses.
Hyperoxia during one lung ventilation: inflammatory and oxidative responses.
复制标题
单肺通气期间的高氧：炎症和氧化反应。
DOI：
10.1002/ppul.22517
复制
发表时间：
2012-10
影响因子：
3.1
通讯作者：
Theroux, Mary C.
中科院分区：
文献类型：
--
作者：
Fisher, Alicia Olivant;Husain, Kamran;Wolfson, Marla R.;Hubert, Terrence L.;Rodriguez, Elena;Shaffer, Thomas H.;Theroux, Mary C.
在单肺通气（OLV）中，使用100%氧气是常见的做法，尽管这可能导致高氧和氧化应激相关的肺损伤。我们假设OLV期间较低的氧（FiO2）可减少炎症和氧化性肺损伤，改善肺功能。将20头猪（8.88±0.84 kg; 38±4.6 d）分为高氧组（n = 10, FiO2 = 100%）和常氧组（n = 10, FiO2 < 50%）。两组均接受3小时的OLV治疗。血液样本检测促炎细胞因子，肺组织检测这些细胞因子和氧化生物标志物。各组间CO2分压、潮气量、潮末CO2、血浆细胞因子或呼吸顺应性均无差异。高氧组总呼吸阻力较大（P = 0.02）。高氧组大鼠肺匀浆中TNF-α、IL-1β、IL-6水平均高于常氧组（P分别≤0.01、0.001、0.001）。高氧组肺匀浆中髓过氧化物酶和蛋白羰基（PC）含量较高（P = 0.03和P = 0.01），超氧化物歧化酶（SOD）含量较低（P≤0.001）。较高的髓过氧化物酶、PC和细胞因子水平以及较低的SOD可用性表明，高氧动物的肺部损伤程度更大，可能是由于使用100%氧气所致。在这项使用猪模型的转化研究中，OLV期间FiO2≤50%可减少高氧损伤并改善肺功能。
It is common practice during one lung ventilation (OLV) to use 100% oxygen, although this may cause hyperoxia- and oxidative stress-related lung injury. We hypothesized that lower oxygen (FiO2) during OLV will result in less inflammatory and oxidative lung injury and improved lung function. Twenty pigs (8.88 ± 0.84 kg; 38 ± 4.6 days) were assigned to either the hyperoxia group (n = 10; FiO2 = 100%) or the normoxia group (n = 10; FiO2 < 50%). Both groups were subjected to 3 hr of OLV. Blood samples were tested for pro-inflammatory cytokines and lung tissue was tested for these cytokines and oxidative biomarkers. There were no differences between groups for partial pressure of CO2, tidal volume, end-tidal CO2, plasma cytokines, or respiratory compliance. Total respiratory resistance was greater in the hyperoxia group (P = 0.02). There were higher levels of TNF-α, IL-1β, and IL-6 in the lung homogenates of the hyperoxia group than in the normoxia group (P ≤ 0.01, 0.001, and 0.001, respectively). Myeloperoxidase and protein carbonyls (PC) were higher (P = 0.03 and P = 0.01, respectively) and superoxide dismutase (SOD) was lower in the lung homogenates of the hyperoxia group (P ≤ 0.001). Higher myeloperoxidase, PC, and cytokine levels, and lower SOD availability indicate a greater degree of injury in the lungs of the hyperoxia animals, possibly from using 100% oxygen. In this translational study using a pig model, FiO2 ≤ 50% during OLV reduced hyperoxic injury and improved function in the lungs.
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影响因子：
120.7
作者：
BIDANI, A;TZOUANAKIS, AE;ZWISCHENBERGER, JB
通讯作者：
ZWISCHENBERGER, JB
影响因子：
3.1
作者：
Miller, TL;Blackson, TJ;Touch, SM
通讯作者：
Touch, SM
影响因子：
2.6
作者：
Rahman, I
通讯作者：
Rahman, I
高氧通过促丝分裂原激活的蛋白激酶增加了呼吸机诱导的肺损伤：一种前瞻性，受控的动物实验。
DOI：
10.1186/cc5704
发表时间：
2007
期刊：
Critical care (London, England)
影响因子：
--
作者：
Li LF;Liao SK;Ko YS;Lee CH;Quinn DA
通讯作者：
Quinn DA
影响因子：
2.1
作者：
Brodsky, Jay B
通讯作者：
Brodsky, Jay B