Effects of stimulus azimuth and intensity on the single-neuron activity in the auditory cortex of the alert macaque monkey.
Effects of stimulus azimuth and intensity on the single-neuron activity in the auditory cortex of the alert macaque monkey.
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DOI：
10.1152/jn.00392.2006
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发表时间：
2006-08
影响因子：
2.5
通讯作者：
T. M. Woods;Steve E. Lopez;James H. Long;Joanne E. Rahman;G. Recanzone
中科院分区：
文献类型：
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作者：
T. M. Woods;Steve E. Lopez;James H. Long;Joanne E. Rahman;G. Recanzone
据推测，灵长类动物的听觉皮层至少由两个处理流组成，其中一个被认为是选择性地处理空间信息。为了测试空间信息是否在不同的听觉皮层领域的差异编码，我们记录了单个神经元在警觉猕猴听觉皮层的宽带噪声刺激，从360度的方位角在四个不同的绝对强度的反应。测试的皮质区域为核心区域A1和喙侧（R），尾侧带区域尾内侧和尾外侧，以及更多的喙侧带区域中外侧和中内侧（MM）。我们发现，几乎所有遇到的神经元都表现出一定的空间调谐。然而，空间选择性的措施表明，尾带领域有最尖锐的空间调谐，A1有中间的空间调谐，R区和MM有最少的空间调谐。虽然大多数神经元显示出对侧空间的最佳反应，但在整个360度的测试空间中观察到最佳方位角。我们还注意到，尽管许多神经元的反应受到眼睛位置的显著影响，但眼睛位置并没有系统地影响我们测量的任何空间依赖性反应。这些数据是一致的假设，尾听觉皮层领域在灵长类动物的过程中的空间特征更准确地比核心和喙带领域。
It has been hypothesized that the primate auditory cortex is composed of at least two processing streams, one of which is believed to selectively process spatial information. To test whether spatial information is differentially encoded in different auditory cortical fields, we recorded the responses of single neurons in the auditory cortex of alert macaque monkeys to broadband noise stimuli presented from 360 degrees in azimuth at four different absolute intensities. Cortical areas tested were core areas A1 and rostral (R), caudal belt fields caudomedial and caudolateral, and more rostral belt fields middle lateral and middle medial (MM). We found that almost all neurons encountered showed some spatial tuning. However, spatial selectivity measures showed that the caudal belt fields had the sharpest spatial tuning, A1 had intermediate spatial tuning, and areas R and MM had the least spatial tuning. Although most neurons showed their best responses to contralateral space, best azimuths were observed across the entire 360 degrees of tested space. We also noted that although the responses of many neurons were significantly influenced by eye position, eye position did not systematically influence any of the spatially dependent responses that we measured. These data are consistent with the hypothesis that caudal auditory cortical fields in the primate process spatial features more accurately than the core and more rostral belt fields.