Fighting fruit flies: A model system for the study of aggression
Fighting fruit flies: A model system for the study of aggression
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DOI：
10.1073/pnas.082102599
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发表时间：
2002-04-16
影响因子：
11.1
通讯作者：
Kravitz, EA
中科院分区：
文献类型：
--
作者：
Chen, S;Lee, AY;Kravitz, EA
尽管攻击性在大多数动物的行为中占有重要地位，但对其直接原因和控制的了解相对较少。为了利用现代遗传分析方法来研究这种复杂的行为，我们开发了一个定量框架来研究常见实验室菌株果蝇的攻击行为。在本研究中，我们分析了73个实验，其中社会幼稚的雄性果蝇在2000多个个体的激动相互作用中相互作用。这使我们能够(t)生成在竞争相互作用中发生的行为的直方图；（ii）计算这些行为的描述性统计数据；(M)通过序列分析确定它们的时间模式。在30分钟的配对试验中，果蝇之间平均包含27个个体的激动相互作用，平均持续11秒，并具有各种强度水平。只有少数比赛发展到最高强度（拳击和扭打）。一项序列分析表明，在行为中反复出现的模式与求爱期间的行为有一些相似之处。基于本报告中所描述的模式，通过使用突变株和其他遗传分析技术来详细检查攻击行为成为可能。
Despite the importance of aggression in the behavioral repertoire of most animals, relatively little is known of its proximate causation and control. To take advantage of modern methods of genetic analysis for studying this complex behavior, we have developed a quantitative framework for studying aggression in common laboratory strains of the fruit fly, Drosophila melanogaster. In the present study we analyze 73 experiments in which socially naive male fruit flies interacted in more than 2,000 individual agonistic interactions. This allows us to (t) generate an ethogram of the behaviors that occur during agonistic interactions; (ii) calculate descriptive statistics for these behaviors; and (M) identify their temporal patterns by using sequence analysis. Thirty-minute paired trials between flies contained an average of 27 individual agonistic interactions, lasting a mean of 11 seconds and featuring a variety of intensity levels. Only few fights progressed to the highest intensity levels (boxing and tussling). A sequential analysis demonstrated the existence of recurrent patterns in behaviors with some similarity to those seen during courtship. Based on the patterns characterized in the present report, a detailed examination of aggressive behavior by using mutant strains and other techniques of genetic analysis becomes possible.