Long and short non-coding RNAs as regulators of hematopoietic differentiation.
Long and short non-coding RNAs as regulators of hematopoietic differentiation.
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长和短的非编码RNA作为造血分化的调节剂。
DOI：
10.3390/ijms140714744
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发表时间：
2013-07-15
影响因子：
5.6
通讯作者：
Diederich M
中科院分区：
文献类型：
--
作者：
Morceau F;Chateauvieux S;Gaigneaux A;Dicato M;Diederich M
基因组分析估计，基因组编码蛋白质的比例对应于约1.5%，而至少66%被转录，这表明许多非编码DNA区域产生非编码RNA（ncRNA）。在过去的二十年里，随着对这些ncRNA在复杂调控网络中的意义的理解，它们在生物学、生理学以及病理学过程中的相关性增加。这篇综述特别关注两大家族的ncRNA，即microRNA（miRNA）和长链非编码RNA（lncRNA）在造血调控中的参与。迄今为止，miRNA已被广泛研究，产生了大量有关加工、调节和作用机制的数据，更具体地说，它们参与造血分化的数据。值得注意的是，miRNA与转录因子调控网络的相互作用是有据可查的，而lncRNA的作用，调节和机制在造血中仍然在很大程度上未被探索;这篇综述收集了有关lncRNA的当前数据以及在正常和病理性造血中的潜在和确认的作用。
Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last two decades with the understanding of their implication in complex regulatory networks. This review particularly focuses on the involvement of two large families of ncRNAs, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the regulation of hematopoiesis. To date, miRNAs have been widely studied, leading to a wealth of data about processing, regulation and mechanisms of action and more specifically, their involvement in hematopoietic differentiation. Notably, the interaction of miRNAs with the regulatory network of transcription factors is well documented whereas roles, regulation and mechanisms of lncRNAs remain largely unexplored in hematopoiesis; this review gathers current data about lncRNAs as well as both potential and confirmed roles in normal and pathological hematopoiesis.
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