Antioxidant and antiviral activities of plastoquinones from the brown alga Sargassum micracanthum, and a new chromene derivative converted from the plastoquinones
Antioxidant and antiviral activities of plastoquinones from the brown alga Sargassum micracanthum, and a new chromene derivative converted from the plastoquinones
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DOI：
10.1248/bpb.28.374
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发表时间：
2005-02-01
影响因子：
2
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Iwashima, M;Mori, J;Hayashi, T
从棕色微花马尾藻（Sargassum micranthum）的甲醇提取物中分离得到两个质体醌类化合物，经光谱分析分别鉴定为2-香叶基香叶基-6-甲基苯醌及其对苯二酚。用改进的Mosher方法，用质体醌转化的色烯衍生物，测定了仲羟基的绝对构型。其中一种质体醌和色烯表现出显著的抗氧化活性，如抑制脂质过氧化作用和对1，1-二苯基-2-苦基肼基（DPPH）的自由基清除作用。发现苯醌类化合物和色烯衍生物对人巨细胞病毒（HCMV）具有有效的抗病毒活性。
Two plastoquinones were isolated from the methanolic extract of the brown alga Sargassum micranthum, and these were identified as a known 2-geranylgeranyl-6-methylbenzoquinone and its hydroquinone, respectively, based on spectroscopic analysis. The absolute configuration of the secondary hydroxyl group was determined by the modified Mosher's method using the new chromene derivative converted from plastoquinones. One of the plastoquinones and the chromene exhibited significant antioxidant activities, such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). The benzoquinone-type compound and the chromene derivative were found to have potent antiviral activity against human cytomegalovirus (HCMV).