CCR 20th anniversary commentary: Preclinical study of proteasome inhibitor bortezomib in head and neck cancer.

CCR 20th anniversary commentary: Preclinical study of proteasome inhibitor bortezomib in head and neck cancer.
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DOI:
10.1158/1078-0432.ccr-14-2550
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发表时间:
2015-03-01
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Van Waes C
Van Waes C
中科院分区:
其他
文献类型:
--
作者:
Allen CT;Conley B;Sunwoo JB;Van Waes C

文献摘要

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在2001年5月1日出版的《临床癌症研究》杂志上发表的一项研究中,Sunwoo及其同事提供了NF-κB和肿瘤发生的蛋白酶体抑制的证据,支持上呼吸消化道实体恶性肿瘤的早期临床试验。随后的临床研究揭示了造血系统恶性肿瘤和实体恶性肿瘤患者的反应二分法以及耐药机制。Clin Cancer Res; 21(5); 942-3。©2015 AACR。参见Sunwoo等人的相关文章,临床癌症研究2001; 2001年5月7(5)日;1419-28
In a study published in the May 1, 2001, issue ofClinical Cancer Research, Sunwoo and colleagues provided evidence for proteasome inhibition of NF-κB and tumorigenesis, supporting early-phase clinical trials in solid malignancies of the upper aerodigestive tract. Subsequent clinical studies uncovered a dichotomy of responses in patients with hematopoietic and solid malignancies, and the mechanisms of resistance.Clin Cancer Res; 21(5); 942–3. ©2015 AACR.See related article by Sunwoo et al., Clin Cancer Res 2001;7(5) May 2001;1419–28