Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
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DOI：
10.4161/trns.2.1.13510
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Kowenz-Leutz, Elisabeth
中科院分区：
文献类型：
--
作者：
Leutz, Achim;Pless, Ole;Kowenz-Leutz, Elisabeth
C/EBPs参与多种细胞功能：调控组织和细胞类型的特定基因表达、增殖和分化控制。C/EBPs有助于能量代谢、女性生殖、先天免疫、炎症、衰老和肿瘤的发展。C/EBP如何实现如此多的功能？在这里，我们讨论了精氨酸和赖氨酸侧链的甲基化对C/EBPs进行了广泛的修饰，并且调控的甲基化深刻地影响了C/EBPs的活性。
C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.