Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications.
Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications.
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DOI：
10.1038/s41581-018-0103-6
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Dong Z
中科院分区：
文献类型：
--
作者：
Guo C;Dong G;Liang X;Dong Z
急性肾损伤（阿基）是一个主要的公共卫生问题与高发病率和死亡率。尽管经过数十年的研究，阿基的发病机制仍然不完全清楚，缺乏有效的治疗方法。越来越多的证据表明表观遗传调控在阿基和肾脏修复过程中的作用，涉及组蛋白修饰、DNA甲基化和各种非编码RNA表达的显著变化。例如，组蛋白乙酰化水平的增加似乎可以保护肾脏免受阿基并促进肾脏修复。阿基还与全基因组和基因特异性DNA甲基化的变化相关;然而，DNA甲基化在肾损伤和修复中的作用和调控在很大程度上仍然难以捉摸。MicroRNA在阿基中已被广泛研究，并且大量特异性microRNA与阿基的发病机制有关。新兴的研究表明microRNA作为阿基的新型诊断生物标志物的潜力。对这些表观遗传机制的进一步研究不仅将产生对阿基和肾脏修复机制的新见解，而且可能导致这种疾病的诊断和治疗的新策略。
Acute kidney injury (AKI) is a major public health concern associated with high morbidity and mortality. Despite decades of research, the pathogenesis of AKI remains incompletely understood and effective therapies are lacking. An increasing body of evidence suggests a role for epigenetic regulation in the process of AKI and kidney repair, involving remarkable changes in histone modifications, DNA methylation and the expression of various non-coding RNAs. For instance, increases in levels of histone acetylation seem to protect kidneys from AKI and promote kidney repair. AKI is also associated with changes in genome-wide and gene-specific DNA methylation; however, the role and regulation of DNA methylation in kidney injury and repair remains largely elusive. MicroRNAs have been studied quite extensively in AKI, and a plethora of specific microRNAs have been implicated in the pathogenesis of AKI. Emerging research suggests potential for microRNAs as novel diagnostic biomarkers of AKI. Further investigation into these epigenetic mechanisms will not only generate novel insights into the mechanisms of AKI and kidney repair but also might lead to new strategies for the diagnosis and therapy of this disease.
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影响因子：
16.6
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