Optic Disc Vascularization in Glaucoma: Value of Spectral-Domain Optical Coherence Tomography Angiography.
Optic Disc Vascularization in Glaucoma: Value of Spectral-Domain Optical Coherence Tomography Angiography.
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DOI：
10.1155/2016/6956717
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发表时间：
2016
影响因子：
1.9
通讯作者：
Labbé A
中科院分区：
文献类型：
--
作者：
Lévêque PM;Zéboulon P;Brasnu E;Baudouin C;Labbé A
目的。目的应用光谱域OCT血管造影术(OCT-A)检测青光眼患者视神经头(ONH)血管的变化。材料和方法。对50例青光眼患者和30例正常人进行OCT-A(AngioVue®，Optovue)检查。测量ONH总血管密度和颞盘血管密度。记录青光眼患者的临床资料、视野参数和光谱域OCT检查(视网膜神经纤维层厚度、GCC：神经节细胞复合体厚度和边缘面积)。分析ONH总血管密度和时间血管密度与结构参数和VF参数的相关性。结果。青光眼组ONH血管密度较对照组降低24.7%(0.412比0.547；p<；0.0001)和22.88%(0.364比0.472；p=0.001)。单因素相关分析显示边缘面积(mm~2)与ONH血管密度(r=0.623；p<；0.0001)和总血管密度(r=0.609；p<；0.0001)呈显著正相关。时间和总的ONH血管密度与RNFL、GCC、VF平均偏差和视野指数显著相关。结论。在青光眼患者中，OCT-A可能检测到与结构和功能性青光眼损害相关的ONH血管密度降低。OCT-A可能成为评价青光眼ONH微循环改变的有用工具。
Purpose. To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A). Material and Method. Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients. Correlations among total and temporal ONH vessel density and structural and VF parameters were analyzed. Results. In the glaucoma group, total and temporal ONH vessel density were reduced by 24.7% (0.412 versus 0.547; p < 0.0001) and 22.88% (0.364 versus 0.472; p = 0.001), respectively, as compared with the control group. Univariate analysis showed significant correlation between rim area (mm2) and temporal ONH vessel density (r = 0.623; p < 0.0001) and total ONH vessel density (r = 0.609; p < 0.0001). Significant correlations were found between temporal and total ONH vessel density and RNFL, GCC, VF mean deviation, and visual field index. Conclusion. In glaucoma patients OCT-A might detect reduced ONH blood vessel density that is associated with structural and functional glaucomatous damage. OCT-A might become a useful tool for the evaluation of ONH microcirculation changes in glaucoma.