Serum levels of soluble interleukin-2 receptor (sIL-2R) in B-chronic lymphocytic leukemia.
Serum levels of soluble interleukin-2 receptor (sIL-2R) in B-chronic lymphocytic leukemia.
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B 慢性淋巴细胞白血病中可溶性白细胞介素 2 受体 (sIL-2R) 的血清水平。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
P. Guglielmo
中科院分区：
文献类型：
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作者：
E. Cacciola;D. Calogero;G. Marra;P. Guglielmo
应用酶联免疫吸附试验检测了20例慢性淋巴细胞白血病患者不同病期外周血及浓缩B细胞悬液上清液中可溶性白细胞介素2受体（sIL-2 R）的水平。在所有血清样品或三分之一的上清液中均发现sIL-2 R水平升高，这可能表明B白血病细胞释放sIL-2 R，而sIL-2 R可能与循环IL-2结合，从而导致B-CLL的免疫调节异常。这一发现，需要进一步调查，可能有预后意义。
By using an enzyme-linked immunosorbent assay, the levels of the soluble form of the interleukin-2 receptor (sIL-2R) were evaluated in the peripheral blood of 20 patients with cell chronic lymphocytic leukemia in different stages of disease and in supernatants obtained from enriched B cell suspensions. In either all serum samples or in one out of three supernatants, elevated levels of sIL-2R were found. This could indicate that the B leukemic cells release sIL-2R which in turn, for its potential capacity of binding circulating IL-2, could contribute to the abnormal immunoregulation which characterizes B-CLL. This finding, which needs further investigation, could have prognostic significance.