Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer
Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer
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DOI：
10.1016/j.bbrc.2009.11.034
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Scorilas, Andreas
中科院分区：
文献类型：
--
作者：
Florou, Dimitra;Papadopoulos, Iordanis N.;Scorilas, Andreas
胃癌是一种预后不佳的恶性肿瘤。在胃癌的发生中起重要作用。本研究描述了细胞凋亡相关基因的分子变化，bcl2-like-12(Bcl2L12)基因的表达。由本课题组成员发现并克隆)，用实时定量聚合酶链式反应方法在具有统计学意义的大小的胃癌和非癌胃组织以及胃癌细胞中进行了研究。Bcl2L12转录本的范围为29-53200个mRNACopies Bcl2L12/10(6)mRNACops Bcl2L12/10(6)mRNACopies Bcl2L12/10(6)mRNACopies Bcl2L12与早期(I/II)胃肿瘤(p=0.044)和肠道组织类型(p=0.034)的显著相关性分别被单因素和多因素分析证实。Bcl2L12与患者无病(p=0.006和p=0.025)和总生存期(p=0.007和p=0.022)的关系。我们的结果为Bcl2L12作为一种新的胃癌预后指标的可能应用开辟了新的视野。(C)2009 Elsevier Inc.保留所有权利
Stomach cancer comprises a malignancy with feeble prognosis. In gastric carcinogenesis. molecular alterations in the apoptosis-related genes hive been described In this study, the expression of BCL2-like-12 (BCL2L12) gene. discovered and cloned by members of our group), Was investigated in a statistically significant sample size of cancerous and non-cancerous stomach tissues and gastric cancer cells with quantitative real-time PCR methodology BCL2L12 transcript was indicated ill cancer gastric tissues to range from 29 to 53200 mRNA copies BCL2L12/10(6) mRNA copies GAPDH Significant associations of BCL2L12 with gastric tumors of the early stages (I/II) (p = 0.044) and of intestinal histotype (p = 0.034) was substantiated Both univariate and multivariate analyses disclosed, respectively, BCL2L12 relationship with disease-free (p = 0.006 and p = 0.025) and overall patients' survival (p = 0.007 and p = 0.022). Our results open new horizons for the possible application of BCL2L12 as a novel prognostic indicator of gastric cancer. (c) 2009 Elsevier Inc All rights reserved