Progressive retinal nerve fibre layer thinning and choroidal microvasculature dropout at the location of disc haemorrhage in glaucoma
Progressive retinal nerve fibre layer thinning and choroidal microvasculature dropout at the location of disc haemorrhage in glaucoma
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DOI：
10.1136/bjophthalmol-2020-316169
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发表时间：
2021-05-01
影响因子：
4.1
通讯作者：
Kim, Tae-Woo
中科院分区：
文献类型：
--
作者：
Kim, Chung Young;Lee, Eun Ji;Kim, Tae-Woo
背景/目的研究原发性开角型青光眼（POAG）和椎间盘出血（DH）患者的视盘旁脉络膜微血管脱落（MvD）是否与进行性视网膜神经纤维层（RNFL）变薄相关。方法对50例原发性开角型青光眼（POAG）合并DH患者行扫频光源光学相干断层扫描（OCT）血管造影（OCTA）检查，分别于术前1年、术前1年、术后1年进行检测。MvD定义为局灶性扇形脱落的乳头旁深层区域，无可见的微血管网络。比较了有和无MvD的眼组中OCT RNFL厚度的进行性变化。结果发现DH后1年MvD的累积患病率为76.0%（38眼）。所有MvD都在与卫生署相同的部门位置被发现。在MvD眼中，从1年前到DH检测时，DH位置的整体RNFL厚度和扇形RNFL厚度均显著降低（均为P
Background/Aims To investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH). Methods Parapapillary microvasculature was evaluated by swept-source optical coherence tomography (OCT) angiography (OCTA) in 50 eyes with POAG and DH, 1 year before, at the time of and 1 year after the detection of DH. MvD was defined as an area in the parapapillary deep layer of focal sectoral dropout with no visible microvascular network. Progressive changes in OCT RNFL thickness were compared in groups of eyes with and without MvD. Results Cumulative prevalence of MvD was 76.0% (38 eyes) at 1 year after detection of DH. All MvDs were detected in the same sectoral locations as DH. In eyes with MvD, global RNFL thickness and sectoral RNFL thickness at the location of DH were significantly reduced, both from 1 year before to the time of DH detection (both p