Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.
Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.
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DOI：
10.1016/j.ydbio.2017.05.006
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发表时间：
2017-07-01
影响因子：
2.7
通讯作者：
Galko MJ
中科院分区：
文献类型：
--
作者：
Tsai CR;Anderson AE;Burra S;Jo J;Galko MJ
Yorkie (Yki), the transcriptional co-activator of the Hippo signaling pathway, has well-characterized roles in balancing apoptosis and cell division during organ growth control. Yki is also required in diverse tissue regenerative contexts. In most cases this requirement reflects its well-characterized roles in balancing apoptosis and cell division. Whether Yki has repair functions outside of the control of cell proliferation, death, and growth is not clear. Here we show that Yki and Scalloped (Sd) are required for epidermal wound closure in the Drosophila larval epidermis. Using a GFP-tagged Yki transgene we show that Yki transiently translocates to some epidermal nuclei upon wounding. Genetic analysis strongly suggests that Yki interacts with the known wound healing pathway, Jun N-terminal kinase (JNK), but not with Platelet Derived Growth Factor/Vascular-Endothelial Growth Factor receptor (Pvr). Yki likely acts downstream of or parallel to JNK signaling and does not appear to regulate either proliferation or apoptosis in the larval epidermis during wound repair. Analysis of actin structures after wounding suggests that Yki and Sd promote wound closure through actin regulation. In sum, we found that Yki regulates an epithelial tissue repair process independently of its previously documented roles in balancing proliferation and apoptosis.
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影响因子：
4.6
作者：
Heallen, Todd;Morikawa, Yuka;Martin, James F.
通讯作者：
Martin, James F.
DOI：
10.1016/j.cub.2010.02.035
发表时间：
2010-04-13
期刊：
Current biology : CB
影响因子：
--
作者：
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通讯作者：
Longmore GD
影响因子：
64.5
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Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
2.7
作者：
Fang X;Adler PN
通讯作者：
Adler PN
影响因子：
4.6
作者：
Fernandez, Beatriz Garcia;Gaspar, Pedro;Janody, Florence
通讯作者：
Janody, Florence