Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis
Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis
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DOI：
10.1016/j.redar.2016.09.004
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发表时间：
2017-03-01
影响因子：
1.3
通讯作者：
Aguilera, L.
中科院分区：
文献类型：
--
作者：
Iriondo, O.;Zaldibar-Gerrikagoitia, J.;Aguilera, L.
1例19岁男性，因服用冰毒4天后出现肌张力障碍运动和定向障碍，发展为紧张性弗兰克综合征，最终发展为癫痫持续状态，来到本院急诊室。确诊为抗NMDA受体脑炎，这是一种源于自身免疫性边缘区域的急性炎症，早期诊断和治疗是最终结果的关键因素。在这种情况下，最初的正常测试和以前的甲基苯丙胺中毒推迟了诊断，因为吸入甲基苯丙胺中毒引起的临床症状类似于抗NMDA受体脑炎。甲基苯丙胺中毒可能引起了患者的免疫反应，导致了病理的进展。(C)2016年西班牙复兴社会。由Elsevier Espana，S.L.U出版。版权所有。
A 19-year-old male came to the Emergency Room of our hospital due to an episode of dystonic movements and disorientation 4 days after consuming methamphetamine, which evolved to a catatonic frank syndrome and eventually to status epilepticus. Definitive diagnosis was anti-NMDA receptor encephalitis, an acute inflammation of the limbic area of autoimmune origin in which early diagnosis and treatment are key elements for the final outcome. In this case, initial normal tests and previous methamphetamine poisoning delayed diagnosis, because inhaled-methamphetamine poisoning causes similar clinical symptoms to anti-NMDA receptor encephalitis. Methamphetamine poisoning may have caused an immune response in the patient, bringing on the progress of the pathology. (C) 2016 Sociedad Espanola de Anestesiologia, Reanimacion y Terapeutica del Dolor. Published by Elsevier Espana, S.L.U. All rights reserved.