Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies
Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies
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DOI：
10.1177/1098612x13511446
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发表时间：
2014-06-01
影响因子：
1.7
通讯作者：
Marks, Steven L.
中科院分区：
文献类型：
--
作者：
Marino, Christina L.;Lascelles, B. Duncan X.;Marks, Steven L.
慢性肾脏疾病（CKD）和退行性关节疾病都被认为是常见的老年猫。缺乏关于这两种疾病共同流行的信息。这项回顾性研究旨在确定两组猫的CKD患病率：从四个均匀分布的年龄组中随机选择的猫（RS组）和为退行性关节疾病研究招募的猫（DJD组），并评估这些队列中CKD和DJD的并发性。RS组从6个月到20岁的4个年龄组中随机选择，DJD组包括之前4项DJD研究中招募的猫，其中两项研究中DJD组不包括血尿素氮和/或血清肌酐浓度bbb20 %（正常上限）的猫，另外两项研究中不包括CKD 3期和4期的猫。RS组和ddd组的CKD患病率分别高于预期的50%和68.8%。CKD在1 - 15岁的猫中很常见，在RS和DJD猫中，CKD 1期和2期的患病率在各年龄组中分别相似。我们发现在所有年龄段的猫中CKD和DJD之间存在显著的一致性，这表明在选择DJD治疗时需要增加CKD筛查。此外，本研究还提出了CKD和DJD之间的关系和因果共性，因为它们在不同年龄组和生命阶段具有显著的一致性。
Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration >20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages.