Confinement-Dependent Diffusiophoretic Transport of Nanoparticles in Collagen Hydrogels
Confinement-Dependent Diffusiophoretic Transport of Nanoparticles in Collagen Hydrogels
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DOI：
10.1021/acs.nanolett.1c02251
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发表时间：
2021-09-13
期刊：
影响因子：
10.8
通讯作者：
Shin, Sangwoo
中科院分区：
文献类型：
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作者：
Doan, Viet Sang;Chun, SungGyu;Shin, Sangwoo
纳米粒子在生物水凝胶中的传输通常受到介质的强烈限制，从而限制了药物输送和消毒等重要应用。在这里，我们研究纳米粒子的胶原蛋白水凝胶中的扩散电泳驱动的运输。相反，共同的期望限制边界限制影响的限制阻碍diffusiophoresis，我们观察到一个非单调的行为，其中最大的diffusiophoretic流动性观察在中间限制。我们发现，这种行为是多个大小依赖的影响之间的相互作用的后果。我们的研究结果显示，在严格限制下，在生理相关的条件下，扩散电泳增强纳米颗粒运输的效用，这表明在压缩组织中的药物递送的潜在策略。
The transport of nanoparticles in biological hydrogels is often hindered by the strong confinement of the media, thus limiting important applications such as drug delivery and disinfection. Here, we investigate nanoparticle transport in collagen hydrogels driven by diffusiophoresis. Contrary to common expectations for boundary confinement effects where the confinement hinders diffusiophoresis, we observe a nonmonotonic behavior in which maximum diffusiophoretic mobility is observed at intermediate confinement. We find that such behavior is a consequence of the interplay between multiple size-dependent effects. Our results display the utility of diffusiophoresis for enhanced nanoparticle transport in physiologically relevant conditions under tight confinement, suggesting a potential strategy for drug delivery in compressed tissues.