Exploring vision-related acupuncture point specificity with multivoxel pattern analysis
Exploring vision-related acupuncture point specificity with multivoxel pattern analysis
复制标题
通过多体素模式分析探索与视觉相关的穴位特异性
DOI：
10.1016/j.mri.2009.11.009
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Li, Linling;Qin, Wei;Tian, Jie
穴位特异性是针灸功能磁共振成像（fMRI）研究的核心问题之一，并一直处于讨论之中。然而，穴位特异性的存在并没有得到强有力的一致性证明，其原因可能与分析方法不当有关。以往的穴位特异性研究大多基于模型方法，由于先验知识的不准确，使得对穴位特异性的探索受到限制。在这里，我们应用多体素模式分析（MVPA），以探讨在视觉相关的穴位（GB 37）和附近的非穴位（NAP）的针刺刺激引起的脑激活模式的特异性。结果表明，多个脑区可以区分这两个部位的针刺刺激引起的中枢神经反应模式，其准确性高于机会水平。这些区域包括枕叶皮质、边缘-小脑区和躯体感觉皮质。我们的研究结果支持，脑皮层的特征神经反应模式，针刺刺激在GB 37和附近的NAP可以有效地与应用MVPA的方法彼此不同。(C)2010年爱思唯尔公司All rights reserved.
Acupoint specificity is one of the central issues of functional magnetic resonance imaging (fMRI) studies of acupuncture and has been under discussed. However, strong and consistent proof has not been provided for the existence of acupoint specificity, and unsuitable analysis approach applied could be the reason. We observed that previous researches of acupoint specificity were mostly based on model-based methods which were limited to make exploration of acupoint specificity because of the inaccurate specified prior. Here we applied multi-voxel pattern analysis (MVPA) to investigate the specificity of brain activation patterns induced by acupuncture stimulations at a vision-related acupoint (GB37) and a nearby nonacupoint (NAP). Results showed that multiple brain areas could differentiate the central neural response patterns induced by acupuncture stimulation at these two sites with higher accuracy above the chance level. These regions included occipital cortex, limbic-cerebellar areas and somatosensory cortex. Our results support that the characteristic neural response patterns of brain cortex to the acupuncture stimulation at GB37 and a nearby NAP could differ from each other effectively with the application of MVPA approach. (C) 2010 Elsevier Inc. All rights reserved.