EXPERIMENTAL CEREBRAL CONCUSSION .1. ELECTRON-MICROSCOPIC STUDY
EXPERIMENTAL CEREBRAL CONCUSSION .1. ELECTRON-MICROSCOPIC STUDY
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DOI：
10.3171/jns.1977.47.4.0525
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发表时间：
1977-01-01
影响因子：
4.1
通讯作者：
PENG, JR
中科院分区：
文献类型：
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作者：
BAKAY, L;LEE, JC;PENG, JR
用铁摆撞击大鼠枕外隆突，引起大鼠脑震荡。这导致意识丧失持续3-10分钟，迅速恢复，无局灶性神经症状。撞击时头部所吸收的能量约为1450克/厘米。光镜检查仅见轻微病理改变；电镜观察显示，脑震荡后30分钟开始出现明显改变，1小时达到峰值，24小时消失。显著的变化包括撞击点（枕皮质）神经元线粒体的严重肿胀和对撞部位（额叶）的细胞外水肿。地形学上，最严重的改变出现在颅脊髓连接处（延髓和上颈髓），包括线粒体和水肿改变。虽然毛细血管内皮间连接处没有明显的开口，但水肿区积聚了外渗的铁蛋白颗粒，表明血脑屏障的通透性短暂增加。
Cerebral concussion was produced in rats by an Fe pendulum hitting the external occipital protuberance. This resulted in loss of consciousness lasting from 3-10 min with prompt recovery and no focal neurological signs. The energy absorbed by the head at the impact was calculated to be about 1450 g/cm. Light microscopic survey showed only minor pathological changes; EM observation revealed considerable alteration which began at 30 min, reached a peak at 1 h and disappeared at 24 h after concussion. The salient changes included severe swelling of the neuronal mitochondria at the point of impact (occiptal cortex) and extracellular edema at the site of contre coup (frontal lobe). Topographically, the most severe alteration was seen in structures at the craniospinal junction (medulla oblongata and upper cervical cord), consisting of mitochondrial and edematous changes. Although there was no visible opening of the capillary interendothelial junctions, extravasated ferritin particles were accumulated in the edematous regions, indicating a transient increase in the permeability of the blood-brain barrier.