The keratocyte: corneal stromal cell with variable repair phenotypes.
The keratocyte: corneal stromal cell with variable repair phenotypes.
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DOI：
10.1016/j.ajo.2006.11.011
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. West-Mays;D. Dwivedi
中科院分区：
文献类型：
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作者：
J. West-Mays;D. Dwivedi
角膜细胞，也称为成纤维细胞，是角膜基质的间质衍生细胞。这些细胞通常是静止的，但它们可以很容易地响应并在损伤后转变为修复表型。提供用于刺激驻留细胞中的伤口反应的自分泌信号的细胞因子和其它生长因子通常由损伤部位处的血小板呈递。然而，由于角膜的无血管性质，许多环境线索来源于上覆上皮。因此，在许多体内角膜伤口愈合环境以及体外培养模型中，已经广泛研究了角膜上皮-角膜细胞相互作用。暴露于不同的上皮衍生因子以及上皮基质的完整性是已知影响角膜细胞反应并决定角膜修复本质上是再生的还是纤维化的因素。最后，最近在角膜基质中鉴定出骨髓来源的干细胞，这表明损伤后角膜细胞表型的调节更加复杂。
Keratocytes, also known as fibroblasts, are mesencyhmal-derived cells of the corneal stroma. These cells are normally quiescent, but they can readily respond and transition into repair phenotypes following injury. Cytokines and other growth factors that provide autocrine signals for stimulating wound responses in resident cells are typically presented by platelets at the site of an injury. However, due to the avascular nature of the cornea many of the environmental cues are derived from the overlying epithelium. Corneal epithelial-keratocyte cell interactions have thus been extensively studied in numerous in vivo corneal wound healing settings, as well as in in vitro culture models. Exposure to the different epithelial-derived factors, as well as the integrity of the epithelial substratum, are factors known to impact the keratocyte response and determine whether corneal repair will be regenerative or fibrotic in nature. Finally, the recent identification of bone-marrow derived stem cells in the corneal stroma suggests a further complexity in the regulation of the keratocyte phenotype following injury.