The different performance among motor tasks during the increasing current intensity of deep brain stimulation of the subthalamic nucleus in rats with different degrees of the unilateral striatal lesion
The different performance among motor tasks during the increasing current intensity of deep brain stimulation of the subthalamic nucleus in rats with different degrees of the unilateral striatal lesion
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DOI：
10.1016/j.neulet.2010.06.004
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发表时间：
2010-08-09
影响因子：
2.5
通讯作者：
Namba, Hiroki
中科院分区：
文献类型：
--
作者：
Fang, Xin;Sugiyama, Kenji;Namba, Hiroki
在帕金森病（PD）动物模型丘脑底核（subthalamic nucleus，DBS）脑深部电刺激（deep brain stimulation，DBS）的所有参数中，刺激电流强度的选择对刺激电荷或电荷密度的影响是可变的和有争议的。为了观察大鼠在STN-DBS过程中几种运动任务的不同表现，我们观察了在0，100，150和200 μ A电流刺激下的行为表现。我们发现，在甲基苯丙胺诱导的旋转行为测试中，DBS功效在200 μ A刺激期间达到最高，而在步进测试和旋转棒测试中，达到最佳改善的临界电流为150 μ A。这些结果表明，在STN-DBS大鼠实验中，不同症状达到最佳疗效的刺激参数是不同的。应根据每项研究的目的，分别根据症状选择适当的刺激参数。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Of all the parameters in the deep brain stimulation (DBS) of the subthalamic nucleus (STN) in the Parkinson disease (PD) animal models, the selection of the stimulation current intensity is alterable and argumentative to affect the stimulation charge or charge density. In order to observe the different performances among several motor tasks during the STN-DBS in rats, we observed the behavioral performance during the stimulation with 0, 100, 150 and 200 mu A currents. We found that the DBS efficacy reached the climax during the 200 mu A stimulation at the methamphetamine-induced rotational behavioral test, however at the stepping test and rotarod test, the critical current were 150 mu A to reach the best improvements. Such findings suggest that the stimulation parameters to reach the climax efficacy among the different symptoms are different during the STN-DBS experiments in rats. The appropriate stimulation parameters should be selected by the symptoms separately according to the aim of each study. (C) 2010 Elsevier Ireland Ltd. All rights reserved.