Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome
Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome
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DOI：
10.1016/j.metabol.2012.08.014
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发表时间：
2013-03-01
影响因子：
9.8
通讯作者：
Fernandez, Maria Luz
中科院分区：
文献类型：
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作者：
Blesso, Christopher N.;Andersen, Catherine J.;Fernandez, Maria Luz
Objective.我们研究了每日鸡蛋喂养，沿着碳水化合物限制，是否会改变代谢综合征（MetS）患者的脂蛋白代谢，影响致动脉粥样硬化脂蛋白谱和胰岛素抵抗。在一项随机、单盲、平行设计中，参与者每天食用3个全蛋（EGG，n = 20）或等量的无蛋黄鸡蛋替代品（EGG，n = 17），作为适度碳水化合物限制饮食（25%-30%能量）的一部分，持续12周。在基线和第12周评估血浆脂质、载脂蛋白（apo）、氧化低密度脂蛋白（oxLDL）、胆固醇酯转移蛋白（CETP）和卵磷脂-胆固醇酰基转移酶（LCAT）活性。通过核磁共振光谱测定脂蛋白颗粒的浓度和大小。所有个体的动脉粥样硬化性血脂异常均得到改善，表现为血浆甘油三酯、apoC-III、apoE、oxLDL、VLDL颗粒直径、大VDL、总IDL、小LDL和中等LDL颗粒的降低（P
Objective. We investigated if daily egg feeding, along with carbohydrate restriction, would alter lipoprotein metabolism and influence atherogenic lipoprotein profiles and insulin resistance in men and women with metabolic syndrome (MetS).Methods. In a randomized, single-blind, parallel design, participants consumed either 3 whole eggs/day (EGG, n = 20) or the equivalent amount of yolk-free egg substitute (SUB, n = 17), as part of a moderately carbohydrate-restricted diet (25%-30% energy) for 12 weeks. Plasma lipids, apolipoproteins (apos), oxidized LDL (oxLDL), cholesteryl ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) activities were assessed at baseline and week 12. Lipoprotein particle concentrations and sizes were measured by nuclear magnetic resonance spectroscopy.Results. Atherogenic dyslipidemia improved for all individuals as evidenced by reductions in plasma triglycerides, apoC-III, apoE, oxLDL, VLDL particle diameter, large VDL, total IDL, small LDL, and medium LDL particles (P