Analysis of repeated measurement data in the clinical trials.
Analysis of repeated measurement data in the clinical trials.
复制标题
DOI：
10.4103/0975-9476.113872
复制
发表时间：
2013-04
影响因子：
2.4
通讯作者：
Singhal R
中科院分区：
文献类型：
--
作者：
Singh V;Rana RK;Singhal R
统计学是临床试验不可或缺的一部分。统计要素涵盖临床试验设计、数据监测、分析和报告。临床医生对统计学概念的扎实理解提高了临床试验的理解力和质量。在生物医学研究中，研究人员经常使用t检验和方差分析来比较感兴趣的组之间的均值，而不考虑数据的性质。在临床试验中，我们记录患者的数据超过两次。在这种情况下，使用标准的方差分析程序是不合适的，因为它在分析中没有考虑受试者之间的观察之间的相关性。为了处理这类研究数据，应使用重复测量ANOVA。本文应用SPSS(社会科学统计软件包)15.0版软件，对阿育吠陀配方达特利劳哈对缺铁性贫血的Pandu Roga(缺铁性贫血)进行多中心临床试验0天、15天、30天、45天4个时间点的数据进行了单因素方差分析。
Statistics is an integral part of Clinical Trials. Elements of statistics span Clinical Trial design, data monitoring, analyses and reporting. A solid understanding of statistical concepts by clinicians improves the comprehension and the resulting quality of Clinical Trials. In biomedical research it has been seen that researcher frequently use t-test and ANOVA to compare means between the groups of interest irrespective of the nature of the data. In Clinical Trials we record the data on the patients more than two times. In such a situation using the standard ANOVA procedures is not appropriate as it does not consider dependencies between observations within subjects in the analysis. To deal with such types of study data Repeated Measure ANOVA should be used. In this article the application of One-way Repeated Measure ANOVA has been demonstrated by using the software SPSS (Statistical Package for Social Sciences) Version 15.0 on the data collected at four time points 0 day, 15th day, 30th day, and 45th day of multicentre clinical trial conducted on Pandu Roga (~Iron Deficiency Anemia) with an Ayurvedic formulation Dhatrilauha.