Risk Factors for Severe Rift Valley Fever Infection in Kenya, 2007
Risk Factors for Severe Rift Valley Fever Infection in Kenya, 2007
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DOI：
10.4269/ajtmh.2010.09-0293
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发表时间：
2010-08-01
影响因子：
3.3
通讯作者：
Breiman, Robert F.
中科院分区：
文献类型：
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作者：
Anyangu, Amwayi S.;Gould, L. Hannah;Breiman, Robert F.
2006年12月至2007年3月，肯尼亚爆发了大规模裂谷热。我们进行了一项研究，以确定与感染和严重疾病相关的风险因素。共有来自424个家庭的861人参加了调查。202名参与者（23%）有急性裂谷热感染的血清学证据。其中52人（26%）患有严重裂谷热疾病，其特点是出血或死亡。急性裂谷热感染的独立危险因素是食用或处理病畜产品（优势比[OR] = 2.53，95%置信区间[CI] = 1.78-3.61，人群归因风险百分比[PAR%] = 19%）和是牧民（OR 1.77，95%CI = 1.20-2.63，PAR% = 11%）。接触流产动物胎儿与RVF病情严重有关（OR = 3.83，95% CI = 1.68-9.07，PAR% = 14%）。食用或处理病畜产品与死亡相关（OR = 3.67，95% CI = 1.07-12.64，PAR% = 47%）。与动物接触有关的接触与急性裂谷热感染有关，而接触蚊子不是独立的风险因素。
A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study to define risk factors associated with infection and severe disease. A total of 861 individuals from 424 households were enrolled. Two hundred and two participants (23%) had serologic evidence of acute RVF infection. Of these, 52 (26%) had severe RVF disease characterized by hemorrhagic manifestations or death. Independent risk factors for acute RVF infection were consuming or handling products from sick animals (odds ratio [OR] = 2.53, 95% confidence interval [CI] = 1.78-3.61, population attributable risk percentage [PAR%] = 19%) and being a herdsperson (OR 1.77,95% CI = 1.20-2.63, PAR% = 11%). Touching an aborted animal fetus was associated with severe RVF disease (OR = 3.83,95% CI = 1.68-9.07, PAR% = 14%). Consuming or handling products from sick animals was associated with death (OR = 3.67,95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors.