Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis.
Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis.
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DOI：
10.1097/shk.0000000000001619
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Scott MJ
中科院分区：
文献类型：
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作者：
Fu G;Deng M;Neal MD;Billiar TR;Scott MJ
血小板通过与其他免疫和非免疫细胞的相互作用，在多种疾病的发病机制中发挥重要的免疫调节作用。脓毒症是美国的主要死亡原因，并且驱动脓毒症病理的许多机制仍未解决。单核细胞在脓毒症发病机制中受到越来越多的关注，并且多项研究将脓毒症早期观察到的血小板-单核细胞聚集体水平增加与脓毒症患者的临床结局相关联。这些发现表明血小板-单核细胞聚集体可能是一个重要的预后指标。然而，导致血小板与单核细胞相互作用和聚集的机制，以及脓毒症期间聚集的影响仍然不清楚。很少有研究真正研究了血小板和单核细胞的功能，尽管大量研究表明血小板和单核细胞在脓毒症期间的炎症和免疫反应中具有不同的功能。本综述的目的是提供我们所知道的血小板-单核细胞相互作用的机制和生物学意义的见解，以及一些技术上的挑战和局限性，在脓毒症发病机制中研究这一重要的潜在机制。提高我们对脓毒症中血小板和单核细胞生物学的理解可能会导致识别新的靶点，这些靶点可用于积极影响脓毒症的结局。
Platelets have been shown to play an important immunomodulatory role in the pathogenesis of various diseases through their interactions with other immune and nonimmune cells. Sepsis is a major cause of death in the United States, and many of the mechanisms driving sepsis pathology are still unresolved. Monocytes have recently received increasing attention in sepsis pathogenesis, and multiple studies have associated increased levels of platelet–monocyte aggregates observed early in sepsis with clinical outcomes in sepsis patients. These findings suggest platelet–monocyte aggregates may be an important prognostic indicator. However, the mechanisms leading to platelet interaction and aggregation with monocytes, and the effects of aggregation during sepsis are still poorly defined. There are few studies that have really investigated functions of platelets and monocytes together, despite a large body of research showing separate functions of platelets and monocytes in inflammation and immune responses during sepsis. The goal of this review is to provide insights into what we do know about mechanisms and biological meanings of platelet–monocyte interactions, as well as some of the technical challenges and limitations involved in studying this important potential mechanism in sepsis pathogenesis. Improving our understanding of platelet and monocyte biology in sepsis may result in identification of novel targets that can be used to positively affect outcomes in sepsis.