Spontaneous regression of metastatic melanoma - Clinical evidence of the abscopal effect
Spontaneous regression of metastatic melanoma - Clinical evidence of the abscopal effect
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DOI：
10.1016/j.ejso.2013.09.026
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发表时间：
2014-01-01
期刊：
影响因子：
3.8
通讯作者：
Peach, A. H. S.
中科院分区：
文献类型：
--
作者：
Bramhall, R. J.;Mahady, K.;Peach, A. H. S.
引言：转移性黑色素瘤知之甚少。原发病灶的消退与不良预后相关，但所有转移性疾病的自发消退显然是有益的。病人自己的免疫反应偶尔出现刺激自发性消退的转移性疾病在melanoma.Patients和方法：我们提出了六个有趣的情况下，完全或几乎完全自发性消退的转移性黑色素瘤，建议可能的原因和审查literature.Results和conclusions：这些情况下显示明确的放射学，病理学或临床证据的自发性消退的转移性黑色素瘤。这仍然是一个知之甚少的现象，需要进一步研究，并可能证明在免疫介导的解决方案的发展有用。(C)2013爱思唯尔有限公司保留所有权利。
Introduction: Metastatic melanoma is poorly understood. Regression of primary lesions has been associated with poor prognosis, but spontaneous regression of all metastatic disease is clearly beneficial. A patient's own immune responses occasionally appear to stimulate spontaneous regression of metastatic disease in melanoma.Patients and methods: We present six interesting cases of complete or nearly complete spontaneous regression of metastatic melanoma, suggest possible causes and review the literature.Results and conclusions: These cases show clear radiological, pathological or clinical evidence of spontaneous regression of metastatic melanoma. This remains a poorly understood phenomena warranting further investigation and may prove useful in the development of immune mediated solutions. (C) 2013 Elsevier Ltd. All rights reserved.