Essential tremor-plus: a controversial new concept.
Essential tremor-plus: a controversial new concept.
复制标题
DOI：
10.1016/s1474-4422(19)30398-9
复制
发表时间：
2020-03
期刊：
影响因子：
48
通讯作者：
Tan, Eng-King
中科院分区：
文献类型：
--
作者：
Louis, Elan D.;Bares, Martin;Benito-Leon, Julian;Fahn, Stanley;Frucht, Steven J.;Jankovic, Joseph;Ondo, William G.;Pal, Pramod K.;Tan, Eng-King
除了重新定义特发性震颤（ET）外，运动障碍学会2018年关于震颤的共识声明还创造了一个新术语：特发性震颤+（ET-plus）。该术语不确定地定义为具有ET特征的震颤，具有临床意义不确定的其他神经学体征。如果ET+是根据基础病理学的差异或预后的明显差异来定义的，那么它将具有有效的科学依据，就像术语帕金森+一样。然而，没有这样的证据，所以这个词的基础是值得怀疑的。事实上，ET+可能仅代表一种状态（即，ET患者在疾病处于更晚期时可能会出现这些额外的临床特征）。我们警告不要创造没有坚实科学基础支持的新术语，并鼓励研究创建根据潜在原因或病理生理学差异定义的特发性震颤子集。
In addition to redefining essential tremor (ET), the 2018 consensus statement of the Movement Disorder Society on tremor coined a new term: essential tremor-plus (ET-plus). This term is uncertainly defined as tremor with the characteristics of ET, with additional neurological signs of uncertain clinical significance. If ET-plus had been defined on the basis of a difference in underlying pathology or an appreciable difference in prognosis, it would have a valid, scientific rationale, as does the term Parkinson-plus. However, there is no such evidence, so the basis for the term is questionable. In fact, ET-plus might only represent a state condition (ie, patients with ET might develop these additional clinical features when the disease is at a more advanced stage). We caution against coining new terms that are not supported by a firm scientific basis and encourage research into the creation of essential tremor subsets that are defined with respect to differences in underlying causes or pathophysiology.