Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)
Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)
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DOI：
10.3892/or.2013.2909
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发表时间：
2014-02-01
期刊：
影响因子：
4.2
通讯作者：
Jiang, Wen G.
中科院分区：
文献类型：
--
作者：
Ji, Jiafu;Jia, Shuqin;Jiang, Wen G.
WNT 1诱导信号通路蛋白-2（WISP-2），也称为CCN 5、CT 58、CTGF-L、CTGF-3、HICP和Cop 1，是属于CCN家族的3种WNT 1诱导蛋白之一。该家族成员已被证明在许多病理生理过程中发挥多种作用，包括细胞增殖、粘附、伤口愈合、细胞外基质调节、上皮-间充质转化、血管生成、纤维化、骨骼发育和胚胎植入。最近的研究表明，WISP-2与肿瘤的发生和恶性转化有关，特别是在乳腺癌、结直肠癌和肝癌中。值得注意的是，它在癌症中的作用似乎取决于细胞/肿瘤类型和微环境。WISP-2与其他2个家族成员在结构上的显著差异可能导致其功能的差异，这导致WISP-2可能作为其他CCN家族成员的显性负调控因子的假设。本文就WISP-2在人类肿瘤中的作用、调控及其机制作一综述。
Wnt1 inducible signalling pathway protein-2 (WISP-2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.