Idiotypic immunization induces immunity to mutated p53 and tumor rejection
Idiotypic immunization induces immunity to mutated p53 and tumor rejection
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独特型免疫诱导对突变 p53 的免疫力和肿瘤排斥
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
I. Cohen
中科院分区：
文献类型：
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作者：
P. Ruiz;R. Wolkowicz;A. Waisman;D. Hirschberg;P. Carmi;Netta Erez;H. Garren;J. Herkel;M. Karpuj;L. Steinman;V. Rotter;I. Cohen
p53分子可能作为一种常见的肿瘤相关抗原，因为肿瘤抑制基因p53突变，并且p53蛋白通常在肿瘤细胞中过表达。我们报告说，有效的免疫p53可以诱导通过独特型网络与突变的p53特异性的单克隆抗体（PAb-240），或与来自互补决定区（CDR）3的可变结构域的轻链（VL）的这种抗体的肽免疫小鼠。免疫小鼠产生针对p53的IgG抗体，并对携带突变p53的肿瘤系产生细胞毒性反应。特异性免疫的小鼠对肿瘤细胞的攻击具有抗性。因此，p53的抗体可能作为免疫原激活对某些肿瘤的抵抗。在基本水平上，这些发现表明，p53免疫网络可能在免疫系统内自然组织。
The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal antibody (PAb-240) specific for mutated p53, or with a peptide derived from the complementarity determining region (CDR) 3 of the variable domain of the light chain (VL) of this antibody. The immunized mice produced IgG antibodies to p53 and mounted a cytotoxic reaction to a tumor line bearing mutated p53. The idiotypically immunized mice were resistant to challenge with the tumor cells. Thus antibodies to p53 might serve as immunogens for activating resistance to some tumors. At the basic level, these findings indicate that a network of p53 immunity may be organized naturally within the immune system.
Meth A 纤维肉瘤细胞表达两种转化突变体 p53 物种。
影响因子：
8
作者：
Eliyahu,D;Goldfinger,N;Pinhasi-Kimhi,O;Shaulsky,G;Skurnik,Y;Arai,N;Rotter,V;Oren,M
通讯作者：
Oren,M
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC
独特型：概念和应用。
DOI：
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发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Nisonoff,A
通讯作者：
Nisonoff,A