NMR studies of conformations and molecular recognition of pyridinio-appended and nicotinamide-appended β-cyclodextrin
NMR studies of conformations and molecular recognition of pyridinio-appended and nicotinamide-appended β-cyclodextrin
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吡啶和烟酰胺β-环糊精的构象和分子识别的NMR研究
DOI：
10.1080/10610279308035178
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
F. Toda
中科院分区：
文献类型：
--
作者：
H. Ikeda;Hyeon;Yi;F. Toda
摘要用核磁共振波谱研究了吡啶基环糊精(β+)和烟酰胺环糊精(β+)的构象。结合核磁共振波谱技术，确定了CDP+的吡啶残基和CDNA+的烟酰胺残基的取向。核磁共振谱表明，形成络合物后，CDP+和CDNA+的空穴形状发生了变化。这种变化取决于客人的体型。CDNA3+可以将色氨酸外消旋体的Cβ位置的1H共振分离成两组对应的对映体。
Abstract The conformations of pyridinio-appended β-cyclodextrin (CDP+) and nicotinamide-appended β-cyclodextrin (CDNA+) were studied by NMR spectroscopy. The orientations of the pyridine residue of CDP+ and the nicotinamide residue of CDNA+ were determined by using a combination of NMR spectroscopic techniques. NMR spectra indicate that the shapes of the cavities of CDP+ and CDNA+ were changed after forming complexes. This change depended on the shape of the guest. CDNA+ could separate the 1H resonances at the Cβ position of racemic tryptophan into two sets of resonances for each enantiomer.