Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster.
Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster.
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DOI：
10.1016/0012-1606(81)90347-x
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发表时间：
1981-01
影响因子：
2.7
通讯作者：
B. Wakimoto;T. Kaufman
中科院分区：
文献类型：
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作者：
B. Wakimoto;T. Kaufman
幼虫表皮结构的片段模式进行了检查，为个人轴承致死基因型与昆虫足基因复合体（ANT-C）。这些结果为该复合体在果蝇体分割中的作用提供了新的证据，并证明ANT-C与双胸复合体一样，对幼虫和成虫组织都有影响。致死基因型涉及新的EMS诱导的病变或显性同源异型突变（AntporAntpScx）的thenapiacomplementation组显示异常的幼虫中胸和后胸。该表型被解释为中胸和后胸向前胸的同源异型转化。我们建议thatAntp+的功能，在启发的中胸的发展以上的前胸水平在腹侧中和后胸。性梳减少互补组，其中包括突变多性梳（Msc）的致死性，其特征是头部形成不完全和缺乏明确的前胸腹侧刚毛带。这些结果表明Scr+是前胸正常发育所必需的，并且与早期基于成体表型的解释一致。另外5个致死互补位点，分配到多线染色体间隔84 A-B 1，2进行了分析。它们与成虫的显性同源异型表型无关。在theW 36，R11，或R14互补组携带致死突变的个体的终端表型表明，这些位点在正常的前部发育和/或身体分割是重要的，并建议功能关系的同源异型突变先前定位于84 A-84 B1，2多线间隔。
The segment pattern of larval cuticular structures was examined for individuals bearing lethal genotypes associated with the Antennapedia gene complex (ANT-C). The results provide new evidence for the role of this complex in body segmentation inDrosophilaand demonstrate that the ANT-C, like the bithorax complex, effects both larval and imaginal tissues. Lethal genotypes involving new EMS induced lesions or dominant homoeotic mutations (AntporAntpScx) of theAntennapediacomplementation group show anomalies in the larval meso- and metathorax. The phenotype is interpreted as a homoeotic transformation of the meso- and metathorax to prothorax. We suggest thatAntp+functions in the elicitation of mesothoracic development above that of a prothoracic level in the ventral meso- and metathorax. The lethality of theSex combs reducedcomplementation group, which includes the mutationMultiple sex combs(Msc), is characterized by incomplete head formation and the lack of definitive prothoracic ventral setal belts. These results indicate thatScr+is necessary for normal development of the prothorax and are consistent with earlier interpretations based on adult phenotypes. Five other lethal complementation sites, assigned to polytene chromosome interval 84A-B1,2 have been analyzed. They are not associated with dominant homoeotic phenotypes in the adult. The terminal phenotype of individuals carrying lethal mutations in theW36,R11, orR14 complementation groups demonstrate that these loci are important in normal anterior development and/or body segmentation and suggest functional relationships to the homoeotic mutations previously localized to the 84A-84B1,2 polytene interval.