Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality
Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality
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DOI：
10.1002/chin.200008287
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发表时间：
2000-02
期刊：
影响因子：
--
通讯作者：
B. Feringa;R. Delden
中科院分区：
文献类型：
--
作者：
B. Feringa;R. Delden
生物分子的同手性，其起源仍然是一个谜，挑战科学家设计的化学系统，提供手性分子通过绝对不对称合成和放大小的立体化学偏置在这样的系统。用圆偏振光对螺旋形、空间拥挤的烯烃1的对映异构体进行光拆分，以及通过触发大量非手性分子在扭曲液晶相中的螺旋排列来转换立体化学信息（2）是手性控制和放大的例子。
Biomolecular homochirality, the origin of which is still a puzzle, has challenged scientists to design chemical systems that provide chiral molecules through absolute asymmetric synthesis and to amplify a small stereochemical bias in such systems. The photoresolution of the enantiomers of helical‐shaped, sterically overcrowded alkene1with circularly polarized light and the transduction of the stereochemical information by triggering the helical arrangement of a large collection of achiral molecules in a twisted nematic liquid crystalline phase (2) are examples of control and amplification of chirality.