Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g
Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g
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DOI：
10.1542/peds.2016-4258
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发表时间：
2017-08-01
期刊：
影响因子：
8
通讯作者：
Stranak, Zbynek
中科院分区：
文献类型：
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作者：
Semberova, Jana;Sirc, Jan;Stranak, Zbynek
目的：动脉导管未闭（PDA）对于极低出生体重（VLBW）婴儿来说仍然是一个具有挑战性的问题，其治疗方法差异很大。我们本研究的目的是记录一组 VLBW 婴儿的动脉导管自然病程，这些婴儿接受了保守的 PDA 治疗，没有进行任何药物或手术干预。 方法：在 2 个欧洲 3 级新生儿单位进行回顾性队列研究。 结果：研究期间共有 368 名 VLBW 婴儿出生。 297 名婴儿没有先天畸形或心脏缺陷，并存活到出院。其中，280 名婴儿接受了真正保守的 PDA 管理。在 237 名 (85%) 未经治疗的婴儿中，PDA 在出院前关闭。 Kaplan-Meier 模型用于记录不同胎龄组 PDA 闭合随时间变化的发生率。 30 周内导管闭合的中位时间分别为 71 天、13 天、8 天和 6 天。对于不同出生体重组，婴儿体重的中位数为 48 天、22 天、9 天和 8 天
OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention.METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units.RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in = 30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing