Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia.
Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia.
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DOI：
10.1016/j.schres.2018.01.003
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发表时间：
2018-07
影响因子：
4.5
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Watsky RE;Gotts SJ;Berman RA;McAdams HM;Zhou X;Greenstein D;Lalonde FM;Gochman P;Clasen LS;Shora L;Ordóñez AE;Gogtay N;Martin A;Barch DM;Rapoport JL;Liu S
儿童期首发精神分裂症(COS)是一种罕见的、严重的成人首发精神障碍(AOS)。我们之前的静息状态功能磁共振研究发现，与对照组相比，COS患者的功能连接性减弱。在这里，我们询问COS和AOS患者及其兄弟姐妹是否表现出类似的功能连接异常。使用全脑、数据驱动的方法评估COS(患者/同胞/对照，n：26/28/33)和AOS(n：19/28/30)的静息状态功能连接性差异。在每个数据组中，年龄、性别或头部运动没有显著差异，正如设计的那样，COS数据集的年龄明显低于AOS。COS和AOS患者在广泛的脑区之间表现出比对照组更低的功能连接性(P<；0.05，校正后)，但他们的兄弟姐妹没有。COS和AOS患者的连接性降低没有显示出幅度差异，也不受发病年龄或药物剂量的影响。聚类分析显示，这些区域分为两个大规模网络：一个是感觉运动网络，另一个是以默认模式网络为中心的网络，但只包括COS中的高阶认知区。在两组患者中，这两个网络之间的连通性降低是显著的(P<；0.05，校正后)。在COS和AOS中发现了共同的功能连接减弱模式，支持儿童期和成年期精神分裂症的连续性。在COS和AOS中，感觉运动区和默认模式区之间的连接都发生了变化，这表明自我监控和感觉预测过程中可能存在异常。兄弟姐妹中没有明显的连接障碍，这表明衰减与状态有关。
Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients and their siblings exhibit similar abnormalities of functional connectivity. A whole-brain, data-driven approach was used to assess resting-state functional connectivity differences in COS (patients/siblings/controls, n: 26/28/33) and AOS (n: 19/28/30). There were no significant differences in age, sex, or head motion across groups in each dataset and as designed, the COS dataset has a significantly lower age than the AOS. Both COS and AOS patients showed decreased functional connectivity relative to controls among a wide set of brain regions (P<0.05, corrected), but their siblings did not. Decreased connectivity in COS and AOS patients showed no amplitude differences and was not modulated by age-at-onset or medication doses. Cluster analysis revealed that these regions fell into two large-scale networks: one sensorimotor network and one centered on default-mode network regions, but including higher-order cognitive areas only in COS. Decreased connectivity between these two networks was notable (P<0.05, corrected) for both patient groups. A shared pattern of attenuated functional connectivity was found in COS and AOS, supporting the continuity of childhood-onset and adult-onset schizophrenia. Connections were altered between sensorimotor areas and default-mode areas in both COS and AOS, suggesting potential abnormalities in processes of self-monitoring and sensory prediction. The absence of substantial dysconnectivity in siblings indicates that attenuation is state-related.
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