Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study.
Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study.
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DOI：
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发表时间：
2000-11
影响因子：
4.4
通讯作者：
D. Hood;J. Odel;X. Zhang
中科院分区：
文献类型：
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作者：
D. Hood;J. Odel;X. Zhang
目的探讨多焦视觉诱发电位（mVEP）对单侧视神经炎（ON）后视神经损害的追踪诊断价值。方法在ON发作后7天内对3例患者进行Humphrey视野和mVEP记录。患者在恢复期（约4 - 7周后）进行重新测试。使用Sutter的多输入程序获得60个局部VEP响应（mVEP），以缩放棋盘图案。分别记录双眼单眼刺激的mVEP。结果：最初，所有三名患者都有广泛的视野缺损，视力下降，视野敏感性差的区域mVEP振幅降低。到4 - 7周，大部分部位的视野恢复到接近正常的灵敏度，视力恢复到20/20。mVEP在所有区域恢复到几乎全振幅，但在许多位置存在实质性延迟。延迟反应与急性期记录的视野丧失区域相关。结论mVEP可用于单侧ON后局部视神经损伤的追踪，该技术可用于观察治疗效果以及验证有关急性视力丧失和随后恢复机制的假设。
PURPOSE To explore the multifocal visual evoked potential (mVEP) as a technique for tracking local optic nerve damage after unilateral optic neuritis (ON). METHODS Humphrey visual fields and mVEP recordings were obtained from three patients within 7 days of an episode of ON. Patients were retested during the recovery phase, approximately 4 to 7 weeks later. The multi-input procedure of Sutter was used to obtain 60 local VEP responses (the mVEP) to a scaled checkerboard pattern. The mVEPs were recorded separately for monocular stimulation of both eyes. RESULTS Initially, all three patients had extensive visual field defects, reduced visual acuity, and depressed mVEP amplitude in regions of poor visual field sensitivity. By 4 to 7 weeks, the fields recovered to near normal sensitivity in most locations, and visual acuity returned to 20/20. The mVEP recovered to nearly full amplitude in all regions, but substantial delays were present in many locations. The delayed responses were associated with regions of visual field loss documented during the acute phase. CONCLUSIONS The mVEP can be used to track local optic nerve damage after unilateral ON. This technique should be useful in observing the effects of treatments as well as in testing hypotheses about the mechanisms underlying both the acute loss of vision and the subsequent recovery.