Structural basis of cortical synchronization .1. Three types of interhemispheric coupling
Structural basis of cortical synchronization .1. Three types of interhemispheric coupling
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DOI：
10.1152/jn.1995.74.6.2379
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发表时间：
1995-12-01
影响因子：
2.5
通讯作者：
Bullier, J
中科院分区：
文献类型：
--
作者：
Nowak, LG;Munk, MHJ;Bullier, J
1.在一氧化二氮加氟烷麻醉的瘫痪猫，在大脑皮质17-18区边缘记录到单单位和多单位活动。计算了86对单单位和99对多单位活动的互相关直方图(CCH)。通过减去移位预测器，去除CCHS中的视觉诱发峰。观察到三种类型的CCH峰：宽度较窄(4~28ms)的T峰、宽度中等(30~100ms)的C峰和宽度较大(100~1000ms)的H峰。极少观察到振荡耦合。这种CCH峰的三方分布类似于早期关于17区和18区之间时间耦合的研究报告。不同类型的峰单独或合并出现。在多单位记录中，不同峰型的组合更常见。所有类型的CCH峰通常都是居中的，这意味着相反半球的单位倾向于同步它们的放电。T峰几乎只出现在具有重叠感受野的单元中，并且优先出现在具有相似最佳取向的单元中。C峰和H峰的相遇率不受感受野位置或最佳方位的影响。发展了一种新的研究时间耦合时程的方法，称为潜刺激CCH。这表明H峰可以在视觉刺激过程中出现，并且其时间过程遵循耦合神经元的视觉反应的时间过程。采用单条或两条同时呈现的光条作为刺激，研究了视觉刺激对H-联结强度的影响。这表明，当刺激改变为两个非相干移动的光条时，在单个移动的光条刺激下观察到的H耦合可以完全消除，而视觉反应几乎没有变化。这与自相关图中H峰的强烈减少有关。这些结果表明，T、C和H峰与高频振荡一起构成了位于不同皮质区域的神经元之间的普遍形式的时间耦合。下面的文章报道了皮质损伤对这些不同类型的偶联的相遇几率和强度的影响。
1. Single-unit and multiunit activities were recorded at the area 17-18 border of each cortical hemisphere in paralyzed cats anesthetized with nitrous oxide supplemented with halothane. Crosscorrelation histograms (CCHs) were computed between 86 pairs of single units and 99 pairs of multiunit activities. Visually evoked peaks in the CCHs were removed by subtracting the shift predictor.2. Three types of CCH peaks were observed: T peaks with narrow widths (4-28 ms), C peaks with intermediate widths (30-100 ms), and H peaks with large widths (100-1,000 ms). Oscillatory coupling was observed rarely. This tripartite distribution of CCH peaks is similar to that reported in an earlier study on the temporal coupling between areas 17 and 18. Different types of peaks occured in isolation or in combination. Combination of different peak types was more often observed in multiunit recordings.3. CCH peaks of all types were usually centered, meaning that units in opposite hemispheres tend to synchronize their discharges.4. T peaks were observed almost exclusively for units with overlapping receptive fields and preferentially for units with similar optimal orientations. No dependence on receptive field position or optimal orientation was observed for the encounter rate of C and H peaks.5. A new method, called the peristimulus CCH, was developed to study the time course of the temporal coupling. This showed that H peaks can occur during visual stimulation and that their time course follows that of the visual responses of the coupled neurons.6. Using one single bar or two simultaneously presented light bars as stimuli, we studied the effect of visual stimulation on the strength of H coupling. This showed that H coupling observed under stimulation with a single moving light bar can be completely abolished, with little change in visual responses, when the stimulus is changed to two noncoherently moving bars. This was related to a strong decrease of the H peaks in the autocorrelograms.7. These results demonstrate that T, C, and H peaks constitute, together with high-frequency oscillations, universal forms of temporal coupling between neurons located in different cortical areas. The following paper reports on the effects of cortical lesions on the encounter rate and strength of these different types of coupling.