Neurobehavior related to epigenetic differences in preterm infants
Neurobehavior related to epigenetic differences in preterm infants
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DOI：
10.2217/epi.15.63
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发表时间：
2015-01-01
期刊：
影响因子：
3.8
通讯作者：
Padbury, James F.
中科院分区：
文献类型：
--
作者：
Lester, Barry M.;Marsit, Carmen J.;Padbury, James F.
早产与影响神经内分泌系统的医学问题有关，改变皮质醇水平，对新生儿神经行为产生负面影响。新生儿神经行为受NR3C1和HSD11B2的DNA甲基化调控。目的：确定HSD11B2和NR3C1甲基化是否与早产儿的神经行为特征相关。患者与方法：对67例早产儿在出院前进行神经行为测定。收集面颊拭子用于DNA提取。结果如下：具有高风险神经行为特征的婴儿比具有低风险神经行为特征的婴儿在NR3C1的CpG3处表现出更多的甲基化，而在HSD11B2的CpG3处表现出更少的甲基化。具有这些特征的婴儿更可能在这些CpG位点上具有NR3C1甲基化增加和HSD11B2甲基化减少。结论：早产与调节与高危神经行为特征相关的皮质醇水平的基因的表观遗传差异有关。
Preterm birth is associated with medical problems affecting the neuroendocrine system, altering cortisol levels resulting in negative effects on newborn neurobehavior. Newborn neurobehavior is regulated by DNA methylation of NR3C1 and HSD11B2. Aim: Determine if methylation of HSD11B2 and NR3C1 is associated with neurobehavioral profiles in preterm infants. Patients & methods: Neurobehavior was measured before discharge from the hospital in 67 preterm infants. Cheek swabs were collected for DNA extraction. Results: Infants with the high-risk neurobehavioral profile showed more methylation than infants with the low-risk neurobehavioral profile at CpG3 for NR3C1 and less methylation of CpG3 for HSD11B2. Infants with these profiles were more likely to have increased methylation of NR3C1 and decreased methylation of HSD11B2 at these CpG sites. Conclusion: Preterm birth is associated with epigenetic differences in genes that regulate cortisol levels related to high-risk neurobehavioral profiles.