Mechanisms of induction of adenosine receptor genes and its functional significance.
Mechanisms of induction of adenosine receptor genes and its functional significance.
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DOI：
10.1002/jcp.21579
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发表时间：
2009-01
影响因子：
5.6
通讯作者：
Ravid, Katya
中科院分区：
文献类型：
--
作者：
Hilaire, Cynthia St.;Carroll, Shannon H.;Chen, Hongjie;Ravid, Katya
腺苷是细胞产生和释放的代谢物，特别是在损伤或应激下。它通过腺苷受体（包括腺苷酸环化酶抑制剂A1和A3以及腺苷酸环化酶刺激剂A2A和A2B）的信号传导来激发保护性或损伤性反应。在同一细胞中可以发现多种腺苷受体类型，包括刺激性和抑制性，这表明特定细胞中腺苷受体表达的仔细平衡对于特定腺苷诱导的反应是必要的。这种平衡可以通过腺苷受体基因在不同刺激下的差异表达来控制。在这里，我们已经审查了一系列的研究，其特点是基础或诱导表达的腺苷受体和共同的以及独特的作用机制，希望正在进行的研究将进一步阐明腺苷受体调节的详细机制，导致潜在的治疗应用。
Adenosine is a metabolite generated and released from cells, particularly under injury or stress. It elicits protective or damaging responses via signaling through the adenosine receptors, including the adenylyl cyclase inhibitory A1, and A3, and the adenylyl cyclase stimulatory A2A and A2B. Multiple adenosine receptor types, including stimulatory and inhibitory, can be found in the same cell, suggesting that a careful balance of adenosine receptor expression in a particular cell is necessary for a specific adenosine-induced response. This balance could be controlled by differential expression of the adenosine receptor genes under different stimuli. Here, we have reviewed an array of studies that have characterized basal or induced expression of the adenosine receptors and common as well as distinct mechanisms of effect, in hopes that ongoing studies on this topic will further elucidate detailed mechanisms of adenosine receptor regulation, leading to potential therapeutic applications.
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