C4B-BINDING PROTEIN, A REGULATORY COMPONENT OF THE CLASSICAL PATHWAY OF COMPLEMENT, IS AN ACUTE-PHASE PROTEIN AND IS ELEVATED IN SYSTEMIC LUPUS-ERYTHEMATOSUS
C4B-BINDING PROTEIN, A REGULATORY COMPONENT OF THE CLASSICAL PATHWAY OF COMPLEMENT, IS AN ACUTE-PHASE PROTEIN AND IS ELEVATED IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1159/000463131
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
DAHLBACK, B
中科院分区：
文献类型：
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作者：
BARNUM, SR;DAHLBACK, B
建立了一种用单克隆和多克隆抗人C4 b结合蛋白（C4 BP）抗体放射免疫测定血清中C4 BP的方法。使用该测定法，测定了健康个体、系统性红斑狼疮（SLE）患者和急性期个体的C4 BP水平。C4 BP水平在SLE患者中显著升高（186%; p = 0.0001），在急性期患者中甚至更高（286%; p = 0.0001）。为了确认个体是否处于急性期反应，评估了血清C反应蛋白（CRP）水平。在急性期反应中，CRP水平比正常人升高100倍，但与C4 BP升高无关（r =-0.031;p = 0.899）。在SLE患者中，CRP水平显著但中度升高（5倍; p = 0.028）。这些数据表明，C4 BP是一种急性期反应物，并在急性期反应期间与CRP差异调节。
A radioimmunoassay using monoclonal and polyclonal antihuman C4b-binding protein (C4BP) antibody was developed to quantitate C4BP in serum. Using the assay, the levels of C4BP in healthy individuals, in patients with systemic lupus erythrematosus (SLE), and in acute-phase individuals were determined. The levels of C4BP are significantly elevated in individuals with SLE (186%; p = 0.0001) and are even higher in individuals during the acute phase (286%; p = 0.0001). To confirm whether or not individuals were in the acute-phase response, serum C-reactive protein (CRP) levels were assessed. In the acute-phase response, CRP levels were 100-fold elevated over normals, but did not correlate with increases in C4BP (r =-0.031;p = 0.899). In SLE patients, the CRP levels were significantly, but moderately, elevated (5-fold; p = 0.028). The data indicate that C4BP is an acute-phase reactant and is differentially regulated from CRP during the acute-phase response.