Imaging brain and immune association accompanying cognitive appraisal of an acute stressor
Imaging brain and immune association accompanying cognitive appraisal of an acute stressor
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DOI：
10.1016/j.neuroimage.2007.08.017
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发表时间：
2008-01-01
期刊：
影响因子：
5.7
通讯作者：
Yamada, Jitsuhiro
中科院分区：
文献类型：
--
作者：
Ohira, Hideki;Isowa, Tokiko;Yamada, Jitsuhiro
急性应激引起自主神经、内分泌和免疫系统的多种反应。认知评价被认为是这种应激反应的一个重要调节器。为了研究伴随应激可控性评估的体内平衡维持系统之间的串扰的脑基质，我们同时使用O-15-水正电子发射断层扫描记录局部脑血流量（rCBF），心血管指数，（心率（HR）和血压（BP））、神经内分泌指标（血液中肾上腺素、去甲肾上腺素和促肾上腺皮质激素（ACTH）的浓度）和免疫指标（血液中淋巴细胞亚群（NK细胞、辅助性T细胞、细胞毒性T细胞和B细胞）的比例）。LC任务导致较少的控制感比HC任务的主题。通过从LC任务中减去HC任务，观察到内侧和外侧眶额皮质（OFC）以及内侧和外侧前额叶皮质（MPFC，LPFC）的rCBF显著增加。更重要的是，在LC任务中，在OFC和MPFC中通常发现rCBF与HR、BP和NK细胞之间的显著正相关，但在HC任务中不存在。本研究结果表明，第一次，前额叶神经网络，包括OFC和MPFC可能是一个关键的区域之间的双向功能联系的大脑和周围的自主和免疫活动伴随着评估的急性应激。(C)2007年爱思唯尔公司All rights reserved.
Acute stress elicits multiple responses in autonomic, endocrine, and immune systems. Cognitive appraisal is believed to be one important modulator of such stress responses. To investigate brain substrates of crosstalks between the homeostasis-maintaining systems accompanying appraisal of stressor controllability, we simultaneously recorded regional cerebral blood flow (rCBF) using O-15-water positron emission tomography, cardiovascular indices (heart rate (HR) and blood pressure (BP)), neuroendocrine indices (concentrations of epinephrine, norepinephrine, and adrenocorticotropic hormone (ACTH) in blood), and immune indices (proportions of subsets of lymphocytes (NK cells, helper T cells, cytotoxic T cells, and B cells) in blood), in 11 male subjects who performed a mental arithmetic task with either high controllability (HC) and low controllability (LC). The LC task resulted in less sense of control in subjects than the HC task. Significant increases of rCBF in the medial and lateral orbitofrontal cortices (OFC), and in the medial and lateral prefrontal cortices (MPFC, LPFC) were observed by subtracting the HC task from the LC task. More importantly, significant positive correlations between rCBF and HR, BP, and NK cells were commonly found in the OFC and MPFC during the LC tasks, but not during the HC tasks. The present results showed for the first time that the prefrontal neural network including the OFC and MPFC might be one pivotal region for bi-directional functional association between the brain and peripheral autonomic and immune activities accompanying appraisal of an acute stressor. (C) 2007 Elsevier Inc. All rights reserved.