Reciprocal interactions between circadian clocks and aging.
Reciprocal interactions between circadian clocks and aging.
复制标题
DOI：
10.1007/s00335-016-9639-6
复制
发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Peirson SN
中科院分区：
文献类型：
--
作者：
Banks G;Nolan PM;Peirson SN
事实上，身体中的所有生物过程都受到内部生物钟的调节，该生物钟根据外部24小时世界不断变化的需求来优化生理和行为表现。这种生物钟在生理和分子水平上经历了许多与年龄相关的变化。虽然这些变化被认为是正常衰老过程的一部分，但越来越多的证据表明，昼夜节律系统的破坏会对衰老产生重大影响，这些影响将对健康产生明显的影响。在这里，我们回顾了目前的数据，生理和核心分子时钟如何随着年龄的变化，以及如何从外部线索的反馈可能会调节昼夜节律系统的老化。
Virtually, all biological processes in the body are modulated by an internal circadian clock which optimizes physiological and behavioral performance according to the changing demands of the external 24-h world. This circadian clock undergoes a number of age-related changes, at both the physiological and molecular levels. While these changes have been considered to be part of the normal aging process, there is increasing evidence that disruptions to the circadian system can substantially impact upon aging and these impacts will have clear health implications. Here we review the current data of how both the physiological and core molecular clocks change with age and how feedback from external cues may modulate the aging of the circadian system.